Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper
Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen.
Here is a draft version of a cheat-sheet that I put together for my winter-quarter human genetics class. It's also part of a book that I am slowly writing on human popgen.
Corrections and other comments very welcome
The lab has identified one of the major mechanisms to explain the very large amount of adaptation driven by viruses in the host virus-interacting proteins (VIPs): changes in protein stability.
#Introduccion: (para hispanohablantes)
Soy un estudiante mexicano realizando mi PhD en la Universidad de Arizona. Naci y estudié en México, en la UASLP, hasta un par de años atrás que appliqué para realizar mi posgrado en USA. Siempre gustoso para hablar de ciencia o mi experiencia en el posgrado.
#introduction I mostly work using in silico experiments and mathematical modeling to understand how properties of biological systems affect their evolution. Some of the topics I have studied include:
The effect of #epistasis in the accumulation and purging of deleterious mutations in organisms with high mutation rates. #mutationload
How the #modularity of
#DevelopmentalProcesses affect the #PhenotypicVariability of biological systems. #IntroductionBias
Brian J. Enquist
Joanna Masel
Jonathan Pritchard
David Enard