A novel bifunctional molecule induces selective nitrosation of BTK. Mechanistically, it first covalent bind to BTK and the release NO, which yielded in the nitrosation of a cysteine side chain. Published in #JACS by Jiangbing Wu, Zhangjian Huang and coworkers (#China)

Read more on doi: 10.1021/jacs.5c07409 or on my page: https://me.organicchemistry.eu/post/nitrosation-jacs-2025/

#Chemistry #Science @chemistry

When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:

https://pubs.acs.org/doi/10.1021/jacs.4c15827

#chemistry #JACS #OrgChem #Science

Novel enantioselective #synthesis of rubriflordilactone B by Gui and colleagues from the Chinese Academy of Science published in #JACS
This is already the second total synthesis of this group, with an interesting reaction cascade as the key reaction in this process.

#chemistry #science #totalsynthesis

https://pubs.acs.org/doi/10.1021/jacs.4c18292

Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).

https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/

#Chemistry #Research #Science #OrgChem

Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS

https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/

#orgchem #chemistry #totalsynthesis #science

Another total synthesis in the spotlight: Already early this year Mingji Dai and his research team described the total synthesis of heilonine in #JACS (doi: 10.1021/jacs.3c13492). This synthesis is short and elegant, using multiple C-H functionalisations and a Nazarov cyclisation for their key step.

Read more: https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-heilonine-from-the-wieland-miescher-ketone-by-mingji-dai-jacs-2024

#chemistry #science #totalsynthesis

Finaalllyyyy.... The first 𝐉𝐀𝐂𝐒 (IF - 14.5)😍🤩...

Special thanks to Felipe Fantuzzi (need any introduction? 3rd paper together🫂) & Holger group (University of Würzburg), Sougata Sarkar Sir (without whom I'd not even have an M.Sc.🙏)... & my mother (for insisting on asking Felipe to start a collaboration)😘😍

Link - https://pubs.acs.org/doi/10.1021/jacs.4c10967

#ACS #jacs #organometallic #computational #collaboration #journal #article #openaccess

Efficient Synthesis of ProTide antivirals: A team from from #Fudan University and #Shanghai Jiao Tong University reporting a copper-catalyzed method for synthesizing chiral phosphates in #JACS.

This research represents a new tool for the synthesis of ProTide nucleoside analogues, providing an efficient route that can enhance the development of antiviral drugs in future studies.

https://doi.org/10.1021/jacs.4c12920

#MedChem #Antivirals #Research #Science #Chemistry

My evening lecture: Total synthesis of cylindrocyclophane A by Davies and Craig published in #Science and the stereoselective synthesis of protides by Shang published in #JACS

https://doi.org/10.1126/science.adp2425

https://doi.org/10.1021/jacs.4c12920