Novel enantioselective #synthesis of rubriflordilactone B by Gui and colleagues from the Chinese Academy of Science published in #JACS
This is already the second total synthesis of this group, with an interesting reaction cascade as the key reaction in this process.
Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS
https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/
Computer-aided synthesis: R. Shenvi and C. Li published in #Nature the total synthesis of 25 picrotoxanes. Their 1,5-HAT key reaction was challenged by β-scission, therefore DFT based calculations helped to design usable intermediates.
Read more on my page: https://me.organicchemistry.eu/post/picrotoxanes-nature-2024/
Total Synthesis of Kasugamycin:
Aminoglycoside antibiotic prepared from naturally derived carbohydrates
https://www.chemistryviews.org/total-synthesis-of-kasugamycin/
#orgchem #glycosides #totalsynthesis #chemistry #chemistryviews #chemviews
Total Synthesis of (+)-Mannolide B
Path to a natural product with a complex, fused hexacyclic scaffold
https://www.chemistryviews.org/total-synthesis-of-mannolide-b/
#totalsynthesis #naturalproducts #chemistry #chemistryviews #chemviews
Another total synthesis in the spotlight: Already early this year Mingji Dai and his research team described the total synthesis of heilonine in #JACS (doi: 10.1021/jacs.3c13492). This synthesis is short and elegant, using multiple C-H functionalisations and a Nazarov cyclisation for their key step.
Total Synthesis of Pleurotin (JACS Au, Y. Q. Long 2024)
Pleurotin is a benzoquinone meroterpenoid that was first isolated in the late 1940s. Since that time, several total syntheses of this compound have been reported. Recently, Ya-Qiu Long and his team from Soochow University (#China) published a novel synthetic route in the journal JACS Au.
Read more here: https://www.organicchemistry.eu/books/total-syntheses-of-natural-products/page/total-synthesis-of-pleurotin-y-q-long-2024
First Total Synthesis of Garajonone
Two-stage synthetic strategy provides access to ryanodane diterpenes, a type of structurally complex natural product
https://www.chemistryviews.org/first-total-synthesis-of-garajonone/
#naturalproducts #totalsynthesis #chemistry #chemistryviews #chemviews
Stasseriolides are a class of polyketide natural products with interesting biological activities, but they are limited in natural abundance. A recent synthesis of stasseriolides A-D by Alois Fürstner's group at the Max Planck Institute für Kohlenforschung reported in Angewandte Chemie employed ring-closing alkyne metathesis, providing access to the natural products and enabling the preparation of analogues.
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