Did you know your immune system can influence your emotions? Discover how IL-17 toggles between anxiety and sociability. #NeuroImmunology #MentalHealth #IL17
https://geekoo.news/how-immune-molecules-shape-our-emotions-the-dual-role-of-il-17/
US citizen from #IL or #IN living abroad? YOU CAN #VOTE & your vote matters!
#FliptheHouse with fine #Democrats Eric Sorensen in #IL17 and Frank Mrvan in #IN01! They reach across party lines to end the chaos in Washington. NOVEMBER IS NOW.
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https://www.mucosalimmunology.org/article/S1933-0219(23)00005-3/fulltext
IL-17 protects the gut by stimulating Paneth cells
#immunology #mucosalimmunology #panethcells #il17 #crohnsdisease
Secukinumab blocks IL-17 and some evidence of efficacy in hidradenitis suppurativa in 2x RCT.
Interesting in so much this is clearly an inflammatory disease in which there is also undoubtedly an infective component.
These studies, along with efficacy of TNF blockade indicates hyperinflammation the main issue.
#immunology #inflammation #hidradenitis #IL17 #secukinumab #RCT #trial #hyperinflammation
RT Paul Ogongo
Our latest work show #IL17 #CD4 #Tcells are preserved in HIV-ART. We identify two subsets of #Th17 cells; 1 specifically enriched for IL17 production to #Mtb but not CMV or SEB; and link between IDO-1 activity and circulating Th17 cells.@AnthonyVanTran @UCSF_EXPM @UCSF_GIVI_CFAR
M. tuberculosis antigen-responsive IL17+ CD4 T cells are disproportionately spared in ART-suppressed HIV biorxiv.org/cgi/content/sh… #biorxiv_immuno
IL-17 cytokines drive biological responses that protect the host against many infections but can also contribute to host pathology in the context of infection and autoimmunity. Here, Kingston Mills highlights the different cellular sources of IL-17 and compares the pathological versus protective functions of these cytokines.
Nice study showing Candida albicans lipase suppressing host IL-17 responses & promotes invasive infection.
Caveats re model systems used, etc.. but interesting demonstration of pathogen evasion of protective host immune responses.
#mycology #immunology #IDMastodon #Science #IL17 #Candida
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(22)00517-0#secsectitle0070
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