"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."

#immunology #Treg

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183

Review at EJI

"Dysregulation or overproduction of IL-6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL-6 in altering the balance between Treg and Th17 cells, controlling IL-6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases."

#Immunology #Treg #Th17 #Autoimmunity

https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201040391

RT Paul Ogongo
Our latest work show #IL17 #CD4 #Tcells are preserved in HIV-ART. We identify two subsets of #Th17 cells; 1 specifically enriched for IL17 production to #Mtb but not CMV or SEB; and link between IDO-1 activity and circulating Th17 cells.@AnthonyVanTran @UCSF_EXPM @UCSF_GIVI_CFAR

M. tuberculosis antigen-responsive IL17+ CD4 T cells are disproportionately spared in ART-suppressed HIV biorxiv.org/cgi/content/sh… #biorxiv_immuno