Caspase enzymes are traditionally known for their roles in late stages of apoptosis, but growing evidence supports their function in non-apoptotic cellular processes. This study shows that caspase-3 and caspase-7 promote cytoprotective autophagy in response to non-lethal stress by modulating PARP1 activity in breast cancer cells.
The mechanisms that drive protein phase transitions are unclear. This study in plants shows that an intracellular liquid condensate formed by the lipid transferase SFH8 associates with membranes; when a short fragment of SFH8 is removed by the caspase-like protease ESP, it transforms into a solid filament that can modulate root development.
ER stress induces #caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with #herpes simplex #virus type 2
#HSV type 2 infection promotes #neuronal #celldeath and #inflammatory responses via #ERstress-dependent #gasdermin E activation.
Søren Paludan and colleagues
Characterization of Gasdermin E-mediated pyroptosis in the basal chordate amphioxus reveals that it is transcriptionally regulated by IRF1/8, involved in bacteria induced tissue damage, and inhibited by caspase inhibitor.
Characterization of Gasdermin E-mediated pyroptosis in the basal chordate amphioxus reveals that it is transcriptionally regulated by IRF1/8, involved in bacteria induced tissue damage, and inhibited by caspase inhibitor.
Characterization of Gasdermin E-mediated pyroptosis in the basal chordate amphioxus reveals that it is transcriptionally regulated by IRF1/8, involved in bacteria induced tissue damage, and inhibited by caspase inhibitor.
Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases
https://www.sciencedirect.com/science/article/pii/S1097276522002192
The findings of this study open up possibilities for further research on the role of ATP in apoptosis, as well as potential therapeutic targets for controlling cell death.
#ATP #Cell #CellDeath #Apoptosis #Caspase-3 #Pannexin-1 #Metabolism #FRET #Biosensors
PLOS Biology
The EMBO Journal
Sarah Melamed
Joseph P.