Mastodawn

Victoria Stuart 🇨🇦 🏳️‍⚧️Aug 31, 2024

U.K. researchers find Alzheimer’s-like brain changes in long COVID patients
https://uknow.uky.edu/research/uk-researchers-find-alzheimer-s-brain-changes-long-covid-patients
https://news.ycombinator.com/item?id=41404748

* cognitive impairments in long COVID patients share striking similarities w. those in Alzheimer’s disease, related dementias

Parallel electrophysiological abnormalities due to COVID-19 infection and to Alzheimer's disease and related dementia
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14089

#COVID #COVID19 #LongCOVID #Alzheimers #mitochondria #fatigue #ChronicFatigue #ERstress #dementia

UK researchers find Alzheimer’s-like brain changes in long COVID patients

New research from the University of Kentucky’s Sanders-Brown Center on Aging shows compelling evidence that the cognitive impairments observed in long COVID patients share striking similarities with those seen in Alzheimer’s disease and related dementias.

UKNow

The EMBO Journal Sep 1, 2023

ER stress induces #caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with #herpes simplex #virus type 2

#HSV type 2 infection promotes #neuronal #celldeath and #inflammatory responses via #ERstress-dependent #gasdermin E activation.

Søren Paludan and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113118

Journal of Experimental Botany Aug 27, 2023

'SMALLER TRICHOMES WITH VARIABLE BRANCHES (#SVB) and its homolog SVBL act downstream of transcription factor NAC089 and function redundantly in #Arabidopsis unfolded protein response'

by Chao-Yuan Yu and Yuki Nakamura of RIKEN Center for Sustainable Resource Science (CSRS)

📖 https://doi.org/10.1093/jxb/erad296

#ERstress #UnfoldedProteinResponse

SMALLER TRICHOMES WITH VARIABLE BRANCHES (SVB) and its homolog SVBL act downstream of transcription factor NAC089 and function redundantly in Arabidopsis unfolded protein response

In the plant unfolded protein response to alleviate endoplasmic reticulum stress, the homologs SVB and SVBL function downstream of the transcription factor NAC0

OUP Academic

Journal of Cell Science Dec 22, 2022

Farias &co show that stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells. Initial peer review @ReviewCommons #openaccess: https://journals.biologists.com/jcs/article/135/23/jcs260294/285214/Stress-induced-phase-separation-of-ERES-components
#cellbiology #research #openscience #phaseseparation #ERstress

Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells

Highlighted Article: ER exit site (ERES) proteins undergo stress-induced redistribution into membraneless Sec bodies in mammals. This depletes them from the ER membrane, which impairs ER exit.

The Company of Biologists

Journal of Cell Science Nov 30, 2022

Rong, Zhou &co from the Key Laboratory of Marine Drugs at Ocean University of China show that genetic deletion of the heat shock factor hspa8 leads to selective tissue malformations in zebrafish embryonic development:
https://journals.biologists.com/jcs/article/135/21/jcs259734/278644/Genetic-deletion-of-hspa8-leads-to-selective
#cellbiology #research #zebrafish #embryonicdevelopment #ERstress

Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development

Summary: Hspa8 (also known as Hsc70), an essential protein for cell survival, has tissue-specific roles via induction of the unfolded protein response in the regulation of zebrafish embryonic development.

The Company of Biologists

Show thread