Soh Kam Yung"Cells that store fat, or adipocytes, and immune cells, such as macrophages, that live in fat tissue can remember weight long after it’s lost. And scientists suggest obesity causes lasting changes to those cells that make it easier to revert the body to a state of obesity, even after significant weight loss."
nf-corePipeline release! nf-core/methylseq v4.2.0 - Tapus Maximus!
Methylation (Bisulfite-Sequencing) analysis pipeline using Bismark or bwa-meth MethylDackel
Please see the changelog: https://github.com/nf-core/methylseq/releases/tag/4.2.0
#bisulfitesequencing #dnamethylation #emseq #epigenome #epigenomics #methylseq #pbat #rrbs #nfcore #openscience #nextflow #bioinformatics
what's trendingRejuvenate Cells, Slow Aging - Jacob Kimmel and Dwarkesh Patel
Pipeline release! nf-core/methylseq v4.1.0 - Burrows Stardust!
Please see the changelog: https://github.com/nf-core/methylseq/releases/tag/4.1.0
#bisulfitesequencing #dnamethylation #emseq #epigenome #epigenomics #methylseq #pbat #rrbs #nfcore #openscience #nextflow #bioinformatics
Pipeline release! nf-core/methylseq v4.0.0 - Wallace Chrysalis!
Please see the changelog: https://github.com/nf-core/methylseq/releases/tag/4.0.0
#bisulfitesequencing #dnamethylation #emseq #epigenome #epigenomics #methylseq #pbat #rrbs #nfcore #openscience #nextflow #bioinformatics
Bianor Biotech, biotecnología de la reproducciónOtro artículo sobre ambiente, estilo de vida e influencia en la fertilidad masculina a través del epigenoma. Desde la capacidad fértil del espermatozoide hasta la descendencia.
https://buff.ly/3E6NhIF
#bianorbiotech #epigenome #environment #lifestyle #MaleFertility #Embryo #OffspringHealth
How do lifestyle and environme...
How do lifestyle and environme...
How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health - Clinical Epigenetics
Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. Paternal diet and obesity are associated with greater risks of metabolic dysfunction in offspring via epigenetic alterations in the sperm. Metabolic changes, such as high blood glucose levels and increased body weight, are commonly observed in the offspring of fathers subjected to chronic stress, in addition to an enhanced risk of depressive-like behaviour and increased sensitivity to stress in both the F0 and F1 generations. DNA methylation is correlated with alterations in sperm quality and the ability to fertilise oocytes, possibly via a differentially regulated MAKP81IP3 signalling pathway. Paternal exposure to toxic endocrine-disrupting chemicals (EDCs) is also linked to the transgenerational transmission of increased predisposition to disease, infertility, testicular disorders, obesity, and polycystic ovarian syndrome (PCOS) in females through epigenetic changes during gametogenesis. As the success of assisted reproductive technology (ART) is also affected by paternal diet, BMI, and alcohol consumption, its outcomes could be improved by modifying factors that are dependent on male lifestyle choices and environmental factors. This review discusses the importance of epigenetic signatures in sperm—including DNA methylation, histone retention, and sncRNA—for sperm functionality, early embryo development, and offspring health. We also discuss the mechanisms by which paternal lifestyle and environmental factors (obesity, smoking, EDCs, and stress) may impact the sperm epigenome.
Pipeline release! nf-core/methylseq v3.0.0 🎉
* Modular Bismark & Bwameth Subworkflows
* GPU Support for Bwameth
* BS-Seq Primer & Updated Documentation
* Run Qualimap & Preseq Options
* Reorganized Configuration Files
See the changelog for details: https://github.com/nf-core/methylseq/releases/tag/3.0.0
#bisulfitesequencing #dnamethylation #emseq #epigenome #epigenomics #methylseq #pbat #rrbs #nfcore #openscience #nextflow #bioinformatics
Steve Dustcircle 🌹#Fatcells have a ‘memory’ of #obesity — hinting at why it’s hard to keep #weight off
Long-lasting changes to the #cells’ #epigenome are linked to a decline in their function.
Pipeline release! nf-core/methylseq v2.7.1 - Shattners Bassoon!
Please see the changelog: https://github.com/nf-core/methylseq/releases/tag/2.7.1
#bisulfitesequencing #dnamethylation #emseq #epigenome #epigenomics #methylseq #pbat #rrbs #nfcore #openscience #nextflow #bioinformatics
Pipeline release! nf-core/methylseq v2.7.0 - Chubby Unicorn!
Please see the changelog: https://github.com/nf-core/methylseq/releases/tag/2.7.0
#bisulfitesequencing #dnamethylation #emseq #epigenome #epigenomics #methylseq #pbat #rrbs #nfcore #openscience #nextflow #bioinformatics
