The #PrimaryCilium regulates several signaling pathways, but what role do these pathways play in #cilium formation? This study shows that modulating Wnt & mTOR signaling affects #ciliogenesis in human retinal epithelial cells @PLOSBiology https://plos.io/45Yg5gB
Loss of a cell biology champion- David Stephens (1971-2024)

We are heartbroken to announce the passing of our dear friend and UK Cilia Network founder David Stephens on October 16, 2024. David was a tireless champion for ECRs in the cell biology field, mentor to many and source of great insight and wisdom across many scientific fields, from membrane trafficking to ...

UK Cilia Network

Deeply saddened by the news that my friend David Stephens died last night.

David was an outstanding cell biologist based at Bristol whose work spanned #MembraneTraffic #cytoskeleton #ciliogenesis and more. He was “one of the good guys”. Kind, supportive, generous with his time, and rigorous about his science. I’ll miss him.

'These findings suggest that an ancestral cRFXa homolog coordinated #ciliogenesis in the progenitors of animals and #choanoflagellates and that the selective deployment of the RFX regulatory module may have been necessary to differentiate ciliated from non-ciliated cell types during early animal evolution.'
#Evolution #CellBiology

https://www.cell.com/current-biology/fulltext/S0960-9822(23)00929-6

A #phylogenetic profiling approach identifies novel #ciliogenesis genes in #Drosophila and C. #elegans
Jeroen Dobbelaere et al Dammermann Lab
https://www.embopress.org/doi/full/10.15252/embj.2023113616
A beautiful story from @MaxCoyle4 @dsboothacosta @Choano_Lab & others first heared of a couple of months back at #LSS2022 @epflSV !
Dive in for more about #RFX #ciliogenesis & #animal #evolution!
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RT @biorxiv_evobio
An RFX transcription factor regulated ciliogenesis in the progenitors of choanoflagellates and animals https://biorxiv.org/cgi/content/short/2022.11.11.515474v1 #biorxiv_evobio
https://twitter.com/biorxiv_evobio/status/1592359855465062401