Tetris, Poker Face & Goofing off…
How do I goof off in my spare time? What about Tetris and children’s names? Well, click on to find out!
https://fedorapancakes.com/2025/05/07/tetris-poker-face-goofing-off/
Tetris, Poker Face & Goofing off…
How do I goof off in my spare time? What about Tetris and children’s names? Well, click on to find out!
https://fedorapancakes.com/2025/05/07/tetris-poker-face-goofing-off/
Why We Do What We Do by Helena Boschi, 2020
Understanding Our Brain to Get the Best Out of Ourselves and Others
Why We Do What We Do combines scientific research with concrete examples and illustrative stories to clarify the complex mechanisms of the human brain. It offers valuable insights into how our brain works every day, at home and at work, and provides practical ideas and tips to help us lead happy, healthy and productive lives.
1-May-2025
Rhythmically trained sea lion returns for an encore—and performs as well as humans
Ronan, the only non-human mammal to demonstrate highly precise beat keeping, continues to challenge our understanding of #biomusicality
The #seaLion at UC Santa Cruz who achieved global fame for her ability to bob her head to a beat is starring in a new study that shows her rhythm is just as precise—if not better—than humans.
https://www.eurekalert.org/news-releases/1082071 #science #mammals #behaviour #rhythm #musicality
Animal research on biomusicality, which looks at whether different species are capable of behaving in ways that show they recognize aspects of music, including rhythm and beat, remains a tantalizing field at the intersection of biology and psychology. Now, the highly trained California sea lion at UC Santa Cruz who achieved global fame for her ability to bob her head to a beat is finally back: starring in a new study that shows her rhythm is just as precise—if not better—than humans.
Animals rely on olfactory cues to guide critical behaviors such as foraging, mate selection, and predator avoidance. Animals discriminate between different odors because each odor binds to a distinct set of olfactory receptor neurons (ORNs). The relationship between the activated ORN class and resulting behavior is an intensely studied problem. Genetic tools in the Drosophila olfactory system make it particularly suitable for understanding this relationship. In this study, we investigate how activity in Or7a-expressing ORNs (Or7a-ORNs) which projects to the DL5 glomerulus, is transformed into aversive behavior. We find that optogenetically activating Or7a-ORNs causes an increase in locomotion speed which results in mild aversion. Surprisingly, silencing the synaptically connected second-order neuron called DL5PN increases the aversion. Silencing DL5PN has no effect on the increase in speed. The increased aversion results from the flies returning to the stimulated area less often. When DL5PN is left intact, flies return more frequently to the stimulated area. Patch-clamp recordings from PNs other than DL5PNs suggest they are activated when Or7a-ORNs are activated. These results suggest that the behavioral effect downstream of a given ORN class is mediated by multiple PN classes. This work advances our understanding of how aversion is encoded and transmitted through early sensory circuits to shape behavior. ### Competing Interest Statement The authors have declared no competing interest.
Day 32 cont 🗳️⚔️🤜🤛👊
As the election gets closer, #extremism and #conflict is happening at polling booths with unruly candidate, party members and constituants.
“A barrage of #complaints about #threatening and #aggressive #behaviour at polling booths has fuelled tension in Australia’s most hotly #contested #electorates and prompted the #ElectoralCommission to warn #candidates in marginal seats that such behaviour would discourage #voters”
#AusPol <https://archive.md/5KgGv> / <https://www.smh.com.au/politics/federal/threats-skulduggery-and-neo-nazis-prompt-aec-warning-about-voting-booths-20250501-p5lvl0.html> (paywall)
Behavioral Neurobiology of PTSD by Eric Vermetten et al, 2018
This volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The collection of articles focuses on both preclinical and clinical reviews of (1) state-of-the-art knowledge of mechanisms of posttraumatic stress disorder (PTSD) and co-occurring disorders.
https://link.springer.com/book/10.1007/978-3-319-94824-9
@bookstodon
#books
#nonfiction
#NeuroBiology
#brain
#behaviour
#PTSD
This volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The book summarizes the latest reviews of mechanisms of PTSD, constructs supporting risk and resiliency for trauma disorders, and novel treatment strategies.
Why We Do What We Do: Understanding Our Brain to Get the Best Out of Ourselves and Others by Helena Boschi, 2020
Why We Do What We Do combines scientific research with concrete examples and illustrative stories to clarify the complex mechanisms of the human brain. It offers valuable insights into how our brain works every day, at home and at work, and provides practical ideas and tips to help us lead happy, healthy and productive lives.
The relationship between bulk transcription factor concentration and DNA binding has been a central question in gene regulation for decades. Recent studies propose that DNA-bound transcription factor hubs, or clusters, aid in fast and precise transcriptional interpretation. Using live imaging techniques, we quantify the concentration, binding, and mobility of the morphogen Dorsal (Dl), both in bulk and in clusters, in Drosophila blastoderm embryo. Our experiments encompass multiple length and time scales, allowing us to obtain a nucleus-wide view of the mechanism connecting hub formation to bulk Dl concentration. Our results show that previously unobserved, slowly-moving clusters of Dl are present, in addition to the expected populations of freely mobile and DNA-bound Dl. Furthermore, both mobile clusters and DNA-bound Dl appear only once a threshold concentration in the nucleus is surpassed, a behavior consistent with liquid-liquid phase separation. Thus, our work elucidates how bulk transcription factor concentration dictates the formation and spatiotemporal changes of different populations needed for gene regulation. ### Competing Interest Statement The authors have declared no competing interest. NIH, , R01GM151409, R01GM139913, R01GM152815 NSF, , MCB-2105619, GRFP Koret-UC Berkeley-Tel Aviv University Initiative in Computational Biology and Bioinformatics, , Winkler Scholar Faculty Award, , Chan Zuckerberg Initiative Grant, , CZIF2024-010479
I’m becoming more and more self-aware how I (over?) explain my self in most of my life contexts.
What I my self think is I don’t want to leave people confused of that I am thinking. So I explain.
How it is also perceived (as I’ve learned) is I am mansplaining.
I’m puzzled and seem not to be able to reach any conclusion whether my behaviour is for the good or for the worse.