Mastodawn

I've been taking an enteric aspirin every evening for my heart for at least 30 years now. No heart attacks so far, so that's good.

But sometimes I get a headache in the evening. I can't take Tylenol or ibuprofen for it, because you're not supposed to mix painkillers; it can cause sudden organ necrosis.

At the same time, I don't like to skip the enteric aspirin. So that's been a problem.

I'm thinking that maybe I should just take regular aspirin for the occasional headache. That way I would still be able to take the enteric aspirin without the danger of mixing different analgesics. What do you think?

#analgesics #aspirin #medical #health

All Scientifical Mar 1

Pain-relieving effect of aspirin #painrelief #aspirin #pharmacology #analgesics ... Continue to: https://www.youtube.com/watch?v=H6WgWYFEv0E

Your Autistic Life FR/EN/ES May 28, 2025

"Have you see... AAAAAAAAAAH!"

"AAAAAAAAAAAAAAAH!"

"What are you doing with your pants down?"

"I'm trying to insert an analgesic."

"Since when are they delivered as suppositories?"

"Since forever. It says right in the name."

"That's not what it means."

"What about those people who take analgesics to deal with constipation?"

"No one, in the entire history of humanity, has ever done that."

"I have."

"Did it work?"

"Well, no, but... oh..."

#analgesics #suppositories #constipation

Howard Smith MD, AM Apr 2, 2025

Regular use of the over-the-counter headache medications acetaminophen or the NSAIDS including ibuprofen led to as much as 21% faster functional concussion recovery. #concussion #headache #analgesics #acetaminoophen #NSAIDS #urtp #daysasymp

https://www.instagram.com/drhowardsmithreports/reel/DH9T5j3NU5v/

Howard G. Smith MD, AM on Instagram: "Common Pain Pills Speed Concussion Recovery Regular use of the over-the-counter headache medications acetaminophen, Tylenol, or the NSAIDS including ibuprofen, Motrin and Advil, led to as much as 21% faster functional concussion recovery. Neurology researchers at Seattle’s University of Washington studied the records of 1661 NAAA athletes and military cadets with a mean age of 18 years and will present their data during this April’s American Academy of Neurology 2025 Annual Meeting. Using activity records pinpointing days until the athletes’s unrestricted return to play (URTP) and time until completely free of symptoms (daysASYMP), the data indicated that over-the-counter pain medication use leads to the 21% faster URTP as well as 15% shorter daysASYMP. These over-the-counter pain medications, analgesics in medical jargon, reduce brain tissue inflammation. Since much of this inflammation occurs within the first 24 hours after injury, that’s the best time to consistently use these analgesics. Even though the NSAID medications are better anti-inflammatories, there was little evidence that they performed better than the acetaminophen. That is likely because both types of painkillers effectively treat headache, and relief of this symptom correlates well with overall recovery. https://www.medscape.com/viewarticle/over-counter-analgesics-improve-concussion-outcomes-2025a100063h #concussion #headache #analgesics #acetaminoophen #NSAIDS #urtp #daysasymp"

0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Common Pain Pills Speed Concussion Recovery Regular use of the over-the-counter headache medications acetaminophen, Tylenol, or the NSAIDS including ibuprofen, Motrin and Advil, led to as much as 21% faster functional concussion recovery. Neurology researchers at Seattle’s University of Washington studied the records of 1661 NAAA athletes and military cadets with a mean age of 18 years and will present their data during this April’s American Academy of Neurology 2025 Annual Meeting. Using activity records pinpointing days until the athletes’s unrestricted return to play (URTP) and time until completely free of symptoms (daysASYMP), the data indicated that over-the-counter pain medication use leads to the 21% faster URTP as well as 15% shorter daysASYMP. These over-the-counter pain medications, analgesics in medical jargon, reduce brain tissue inflammation. Since much of this inflammation occurs within the first 24 hours after injury, that’s the best time to consistently use these analgesics. Even though the NSAID medications are better anti-inflammatories, there was little evidence that they performed better than the acetaminophen. That is likely because both types of painkillers effectively treat headache, and relief of this symptom correlates well with overall recovery. https://www.medscape.com/viewarticle/over-counter-analgesics-improve-concussion-outcomes-2025a100063h #concussion #headache #analgesics #acetaminoophen #NSAIDS #urtp #daysasymp".

Instagram

Howard Smith MD, AM Mar 11, 2025

Ice Cream Gets Your Kid Though A Tonsillectomy: Children consuming ice cream reported significantly less pain. #tonsillectomy #icecream #pain #analgesics
https://www.instagram.com/reel/DHD1deAvsDU/

Howard G. Smith MD, AM on Instagram: "Ice Cream Gets Your Kid Though A Tonsillectomy A clinical trial just published in the International Journal of Pediatric Otolaryngology found that children who ate ice cream after surgery had better pain control compared to those who didn’t. The study group included 48 children undergoing this common childhood surgery. The data showed that, at 6, 12, and 18 hours post-op, children consuming ice cream reported significantly less pain, required less pain medication, and were able to resume oral intake sooner. The ice cream did not trigger an increase in post-operative complications. Children recovering from a tonsillectomy do need some non-narcotic pain medications. Cold, sweet ice cream does help the medicine go down. https://www.sciencedirect.com/science/article/abs/pii/S0165587625000412 #tonsillectomy #icecream #pain #analgesics"

0 likes, 0 comments - drhowardsmithreports on March 11, 2025: "Ice Cream Gets Your Kid Though A Tonsillectomy A clinical trial just published in the International Journal of Pediatric Otolaryngology found that children who ate ice cream after surgery had better pain control compared to those who didn’t. The study group included 48 children undergoing this common childhood surgery. The data showed that, at 6, 12, and 18 hours post-op, children consuming ice cream reported significantly less pain, required less pain medication, and were able to resume oral intake sooner. The ice cream did not trigger an increase in post-operative complications. Children recovering from a tonsillectomy do need some non-narcotic pain medications. Cold, sweet ice cream does help the medicine go down. https://www.sciencedirect.com/science/article/abs/pii/S0165587625000412 #tonsillectomy #icecream #pain #analgesics".

Instagram

Channelomics Dec 23, 2024

State-Dependent Inhibition of Nav1.8 Sodium #IonChannels by the #analgesics VX-150 and VX-548 |
Sorry £¥$€ again

Molecular Pharmacology http://molpharm.aspetjournals.org/content/106/6/298

State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548

Nav1.8 sodium channels (Nav1.8) are an attractive therapeutic target for pain because they are prominent in primary pain-sensing neurons with little expression in most other kinds of neurons. Recently, two Nav1.8-targeted compounds, VX-150 and VX-548, have shown efficacy in clinical trials for reducing pain. We examined the characteristics of Nav1.8 inhibition by these compounds. The active metabolite form of VX-150 (VX-150m) inhibited human Nav1.8 channels with an IC50 of 15 nM. VX-548 (suzetrigine) was even more potent (IC50 0.27 nM). Both VX-150m and VX-548 had the unusual property of “reverse use-dependence,” whereby inhibition could be relieved by repetitive depolarizations, a property seen before with another Nav1.8 inhibitor, A-887826. The relief of VX-548 inhibition by large depolarizations occurred with a time constant of ∼40 milliseconds that was not concentration-dependent. Reinhibition at negative voltages occurred with a rate that was nearly proportional to drug concentration, consistent with the idea that relief of inhibition reflects dissociation of drug from the channel and reinhibition reflects rebinding. The relief of inhibition by depolarization suggests a remarkably strong and unusual state-dependence for both VX-150m and VX-548, with very weak binding to channels with fully activated voltage sensors despite very tight binding to channels with voltage sensors in the resting state. SIGNIFICANCE STATEMENT The Nav1.8 sodium channel (Nav1.8) is a current target for new drugs for pain. This work describes the potency, selectivity, and state-dependent characteristics of inhibition of Nav1.8 channels by VX-150 and VX-548, compounds that have recently shown efficacy for relief of pain in clinical trials but whose mechanism of interaction with channels has not been described. The results show that the compounds share an unusual property whereby inhibition is relieved by depolarization, demonstrating a state-dependence different from most sodium channel inhibitors.

Molecular Pharmacology

Howard Smith MD, AM Apr 4, 2024

Topical Pain Killers Are Toxic: Skin creams used after tattooing, piercings, laser hair removal, and dermabrasion vcontain the local anesthetic lidocaine in concentrations that are dangerously high. #topical #analgesics #lidocaine #tattoo #piercing #dermabrasion #hairremoval
https://www.instagram.com/p/C5Wu4hYLn2O/

Queer Lit Cats Aug 11, 2023

Jezebel: Sex. Celebrity. Politics. With Teeth: The Republican Tears, Fantasy Romance, and Revisionist Westerns That Got Us Through the Week https://jezebel.com/the-republican-tears-fantasy-romance-and-revisionist-1850730510 #Jezebel #archostvportablevideoplayerpvp #norabiettetimmons #laurentousignant #audraheinrichs #annemccaffrey #laurabassett #euphoriants #neilmaskell #piperidines #kyliecheung #harrypotter #caitlincruz #analgesics #emilyblunt #williejack #norabiette #sarahrense #willelora #roe

The Republican Tears, Fantasy Romance, and Revisionist Westerns That Got Us Through the Week

This is the best of what we've been reading, watching, and listening to for your weekend enjoyment.

Jezebel

[email protected] moved Aug 4, 2023

https://www.nejm.org/doi/full/10.1056/NEJMoa2209870

Nuevo medicamento para dolor agudo, inhibe selectivamente un canal de sodio exclusivo de las neuronas nociceptivas de los ganglios de la raíz dorsal.

Que no mencionen en el abstract la comparación con la hidrocodona/paracetamol, e inventen un índice complicado para “medir dolor” que finalmente parece disminuyó sólo 20% respecto a placebo (el estándar es 30%-50%), no da mucha confianza sobre su eficacia.

El tiempo lo dirá 🤷🏽‍♂️

#Dolor #Analgesia #Pain #Analgesics