Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago introduced the concept of #TrainedImmunity.

Today, we invite research to a new Focus Issue on Trained Immunity. Find out more and spread the word. #Immunology
https://elifesciences.org/inside-elife/e4eb2612/focus-issue-call-for-papers-in-trained-immunity?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Nice papers that #neutrophils can also be epigenetically reprogrammed by infection - stemming from effects on stem cells.

Both use #zebrafish as model

#Shigella: https://www.science.org/doi/full/10.1126/sciadv.adf9706

#Salmonella: https://www.science.org/doi/10.1126/sciadv.adf9904
#trainedimmunity #immunology #epigenetics

Fascinating to see #trainedimmunity used to condition immunomodulatory responses.

I guess it's about inducing the right #epigenetic programme, and then the functional effect can be anything.
#immunology #macrophages @JExpMed #tolerance #immunmodulation #science
https://rupress.org/jem/article/220/11/e20221388/276204/Trained-immunity-of-alveolar-macrophages-enhances?guestAccessKey=6d53512f-5c93-4720-8180-9180f44cda67&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2q1v95-cqesgb-cwe4ixj4

More evidence of #trainedimmunity in #COVID19 / #SarsCoV2 infection leading to #Hyperinflammation

#immunology #virology #infectiousdiseases #IDMastodon #medicine

https://www.cell.com/cell/fulltext/S0092-8674(23)00796-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423007961%3Fshowall%3Dtrue

An impressive panorama of Trimethylamine N-oxide/TMAO on👤aortic #EndothelialCell
⏫Traits of #TrainedImmunity/Inflammation
Metabolic reprogramming
Kinome & transcriptional network

Intriguing role of PERK & mitoROS

In addition to Liver, Aorta (#SmoothMuscleCell/#Pericyte/Fibroblast/Mɸ?) may🤔 also oxidize #GutMicrobiota-derived trimethylamine/TMA into Trimethylamine N-oxide/TMAO

What is the local/Aortic vs circulating TMAO level?🧐

Wait for🐭tissue-specific KO of FMO3 (Oxidizing TMA)😆

Dr. Xiaofeng Yang lab JCI insight 2022
https://insight.jci.org/articles/view/158183