News Release 11-Jun-2026

New study shows metformin given during acute COVID-19 infection reduced risk of clinician-diagnosed long COVID by 50%

https://www.eurekalert.org/news-releases/1131805

Full paper:
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag335/8702406

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

RE: https://disabled.social/@tomkindlon/116721885357123392

Another thing kids with Long COVID aren't faking: how sensitive their eyes are to light.

This is not "in their heads", it shows up in measure after measure after measure.

https://www.nature.com/articles/s41598-026-54086-y

#COVID #COVID19 #SARSCov2 #LongCOVID #CovidIsNotOver

RE: https://disabled.social/@tomkindlon/116717085328668673

This study used a self-report for primary outcome, and found

Some secondary outcomes did have high posterior probabilities of efficacy, including 0.98 for symptom burden on day 120 and 0.96 for clinician diagnosis of long COVID on day 180.

So I think the real result from this study is "the study was underpowered" and not "metformin doesn't work for LC" because their results also cannot be distinguished from "metformin during acute COVID-19 reduces Long COVID rate by a quarter"

People who got Metformin:

• were 24% less likely to self-report Long COVID at 180 days
• were 22% less likely to be clinically diagnosed with Long COVID at 180 days

and consider their conclusion:

Metformin did not exceed the primary outcome threshold for declaring efficacy for reducing PASC. The posterior probability of efficacy for metformin was high for preventing a clinician diagnosis of long COVID and for symptom burden, consistent with prior clinical trial and observational data. No safety concerns occurred in this trial of metformin in low-risk adults. While a low event rate makes it challenging to evaluate therapeutics

https://dx.doi.org/10.1093/cid/ciag335

#COVID #COVID19 #SARSCoV2 #LongCOVID #Metformin #PASC

Prioritizing long COVID related single nucleotide polymorphisms by mining genome-wide association studies of COVID-19 susceptibility and hospitalization

https://www.frontiersin.org/journals/systems-biology/articles/10.3389/fsysb.2026.1797543/full

Screenshot from Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Long Covid Advocacy @LongCovidAdvoc : Commentary on the Long Covid article by Alan Levinovitz in WIRED magazine

https://longcovidadvocacy.substack.com/p/commentary-on-the-long-covid-article

https://archive.is/20260601111253/https://www.wired.com/story/the-painful-truth-about-long-covid/

Screenshot from Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome #LC #Covidlonghaulers #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Metformin on the Presence of COVID-19 Symptoms 6 Months after Infection: The ACTIV-6 Randomized Clinical Trial

https://dx.doi.org/10.1093/cid/ciag335

"Metformin did not exceed the primary outcome threshold for declaring efficacy for reducing PASC."

@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@[email protected] #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid #novid @[email protected] #CovidIsNotOver #auscovid19