SBGridMay 22

SBGrid's eLife paper received a citation in April from Antonina Roll-Mecak from the The National Institutes of Health in Nature Structural and Molecular Biology: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state.

Read more here: https://www.nature.com/articles/s41594-026-01787-7?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=610&lea=37746&ctr=0&par=1&trk=a0NNv000001jZ5tMAE

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Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state - Nature Structural & Molecular Biology

Zehr et al. revealed the 2.7-Å cryo-electron microscopy reconstruction of human microtubules in situ in the axon of induced pluripotent stem cell (iPS cell)-derived neurons. It shows an expanded microtubule lattice yet bound to GDP, in contrast to the compacted lattice observed at the iPS cell stage.

Nature
MyMonitor365May 21
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SBGridApr 22

SBGrid member Stuart Orkin, the Harvard Medical School David G. Nathan Distinguished Professor of Pediatrics at Dana-Farber Cancer Institute and Boston Children's Hospital, has been awarded the 2026 Breakthrough Prize in Life Sciences.

Read more here: https://hms.harvard.edu/news/harvard-medical-school-professor-stuart-orkin-wins-2026-breakthrough-prize?utm_source=SilverpopMailing&utm_medium=email&utm_campaign=Daily%20Gazette%2020260421%20(1)

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SBGridApr 16

SBGrid's eLife paper received a citation in March from Dhirendra Simanshu and Anna Maciag from the Frederick National Laboratory for Cancer Research in @Cancer Discovery: Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.

Read more here: https://doi.org/10.1158/2159-8290.CD-25-1280

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