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SBGridOur member tale for March features Andrés Palencia from the Institute for Advanced Biosciences, INSERM in Grenoble, France where his group is harnessing the matchmaking qualities of the LeuRS enzyme in efforts to advance a new class of drugs to tackle drug-resistant bacteria and parasites.
Read more here: https://medium.com/sbgrid-community-news/structure-guided-antibiotics-cc4718d658d8?postPublishedType=repub
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SBGrid's eLife paper received a citation in February from Ed Twomey from The Johns Hopkins University School of Medicine and Dylan Hale (now at University of Pittsburgh) in Nature Communications: Structural basis for activation and conformational plasticity of the GluA4 AMPA receptor.
Structural basis for activation and conformational plasticity of the GluA4 AMPA receptor - Nature Communications
Fast excitatory neurotransmission is mediated by AMPA receptors. Here, the authors discover that the GluA4 AMPA receptor subunit has distinct structural properties and conformational plasticity that tune its activation to glutamate.
Sofia JadeLong‑Distance Caregiving Challenges explores the emotional and practical obstacles of caring from afar and offers supportive tips to stay connected and effective. Read more: https://www.onecaregiversjourney.com/long-distance-caregiving-challenges/
#Caregiving #LongDistanceCare #FamilySupport #CaregiverLife #StayConnected #CaregivingTips
SBGrid's eLife paper received a citation in February from Philip Kranzusch from Dana-Farber Cancer Institute in Nature: Nucleotide signals coordinate activation and inhibition of bacterial immunity.
Nucleotide signals coordinate activation and inhibition of bacterial immunity - Nature
Biochemical and structural studies show that the bacterial dGTPase CloA is activated by virally produced dTTP and inhibited by 5′-triphosphothymidyl-3′5′-thymidine produced by its regulatory partner CloB, and thereby balances antiviral defence and immune-mediated toxicity.
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