SBGrid

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74 Followers
87 Following
696 Posts
SBGrid Consortiumhttps://sbgrid.org/
BioGridshttps://biogrids.org//
SBGrid Data Bankhttps://data.sbgrid.org/
Sliz Labhttps://www.slizlab.org/
SBGrid14h ago

SBGrid's eLife paper received a citation in February from Philip Kranzusch from Dana-Farber Cancer Institute in Nature: Nucleotide signals coordinate activation and inhibition of bacterial immunity.

Read more here: https://www.nature.com/articles/s41586-026-10135-0?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=608&lea=37746&ctr=0&par=1&trk=a0NNv000001bAZJMA2

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Nucleotide signals coordinate activation and inhibition of bacterial immunity - Nature

Biochemical and structural studies show that the bacterial dGTPase CloA is activated by virally produced dTTP and inhibited by 5′-triphosphothymidyl-3′5′-thymidine produced by its regulatory partner CloB, and thereby balances antiviral defence and immune-mediated toxicity.

Nature
SBGrid3d ago

SBGrid's eLife paper received a citation in February from Anthony Kossiakoff from The University of Chicago in @PNASNews: Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.

Read more here: https://www.pnas.org/doi/abs/10.1073/pnas.2512532123?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid+Newsletters&org=1935&lvl=100&ite=608&lea=37746&ctr=0&par=1&trk=a0NNv000001bAZJMA2

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SBGrid4d ago

New Title Alert: vossvolvox- a C++17 command-line tools for analyzing molecular structures, specifically for computing volumes, channels, cavities, and tunnel geometry from various molecular input formats. Intended for structural biology and molecular biophysics.

Learn more here: https://github.com/vosslab/vossvolvox

#SBGrid #SBGridSoftware

GitHub - vosslab/vossvolvox: This repository provides C++17 command-line tools for analyzing molecular structures by computing volumes, channels, cavities, and tunnel geometry from PDB, mmCIF, PDBML, or XYZR inputs. It is intended for researchers in structural biology and molecular biophysics who need reproducible grid-based analyses.

This repository provides C++17 command-line tools for analyzing molecular structures by computing volumes, channels, cavities, and tunnel geometry from PDB, mmCIF, PDBML, or XYZR inputs. It is inte...

GitHub
SBGrid5d ago

SBGrid's eLife paper received a citation in February from Alireza Ghanbarpour from Washington University School of Medicine in St. Louis, in Nature: Bacterial immune activation via supramolecular assembly with phage triggers.

Read more here: https://www.nature.com/articles/s41586-025-10060-8?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=608&lea=37746&ctr=0&par=1&trk=a0NNv000001bAZJMA2

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Bacterial immune activation via supramolecular assembly with phage triggers - Nature

An antiphage defence system has an activation mechanism that relies on the sensing of phage-encoded proteins that enforce geometry crucial to activation and are not typically present in non-infected cells.

Nature
SBGrid6d ago

Technical Notes:

Phenix 2 / Coot 1 integration update: The Phenix/Coot GUI integration is not currently working; the Phenix developers are targeting a fix for their next official release.

SBGridMar 23

SBGrid's eLife paper received a citation in February from Christopher Garcia from Stanford University School of Medicine in @SciMag : Structural ontogeny of protein-protein interactions.

Read more here: https://www.science.org/doi/full/10.1126/science.adx6931?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=608&lea=37746&ctr=0&par=1&trk=a0NNv000001bAZJMA2

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SBGridMar 20

Technical Notes:

SBGrid on HPC: We've published some initial documentation on using individual or group SBGrid installations on HPC resources where creating a `/programs/` link is problematic. Please contact us at [email protected] if you encounter problems or identify areas for improvement. We welcome your feedback

Learn more about Using SBGrid Programs on HPC Clusters with Apptainer: https://docs.sbgrid.org/usage/apptainer/

HPC/Apptainer - SBGrid Documentation

SBGridMar 19

SBGrid's eLife paper received a citation in February from Oriana F. from Wesleyan University and Titus Boggon from Yale University in Nature Communications: Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression.

Read more here: https://www.nature.com/articles/s41467-026-69595-7?utm_source=AdaptiveMailer&utm_medium=email&utm_campaign=SBGrid%20Newsletters&org=1935&lvl=100&ite=608&lea=37746&ctr=0&par=1&trk=a0NNv000001bAZJMA2

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Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression - Nature Communications

Loss of KRIT1 or CCM2 drives harmful KLF4 overexpression in brain vessels. Here, authors show a single KRIT1 must recruit two CCM2 proteins via dual PTB-NPxF interactions to suppress KLF4, revealing a previously unknown PTB clustering mechanism.

Nature
SBGridMar 18

In case you missed Joshua Mitchell webinar featuring Open Force Field Initiative, it is now available in our YouTube channel.

More here: https://youtu.be/4tyxCzrBreQ

#SBGrid #Webinars #ScienceMatters

SBGridMar 18

Member News: SBGrid member Andrew Kruse, professor of biological chemistry and molecular pharmacology in the Blavatnik Institute at Harvard Medical School is featured in The Harvard Gazette for his discovery offering hope for patients with hard-to-treat heart disease.

Read more here: https://news.harvard.edu/gazette/story/2026/03/i-think-i-know-how-to-fix-this/

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