| SBGrid Consortium | https://sbgrid.org/ |
| BioGrids | https://biogrids.org// |
| SBGrid Data Bank | https://data.sbgrid.org/ |
| Sliz Lab | https://www.slizlab.org/ |
Technical Notes:
SBGrid on HPC: We've published some initial documentation on using individual or group SBGrid installations on HPC resources where creating a `/programs/` link is problematic. Please contact us at [email protected] if you encounter problems or identify areas for improvement. We welcome your feedback
Learn more about Using SBGrid Programs on HPC Clusters with Apptainer: https://docs.sbgrid.org/usage/apptainer/
SBGrid's eLife paper received a citation in February from Oriana F. from Wesleyan University and Titus Boggon from Yale University in Nature Communications: Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression.
Loss of KRIT1 or CCM2 drives harmful KLF4 overexpression in brain vessels. Here, authors show a single KRIT1 must recruit two CCM2 proteins via dual PTB-NPxF interactions to suppress KLF4, revealing a previously unknown PTB clustering mechanism.
In case you missed Joshua Mitchell webinar featuring Open Force Field Initiative, it is now available in our YouTube channel.
More here: https://youtu.be/4tyxCzrBreQ
Member News: SBGrid member Andrew Kruse, professor of biological chemistry and molecular pharmacology in the Blavatnik Institute at Harvard Medical School is featured in The Harvard Gazette for his discovery offering hope for patients with hard-to-treat heart disease.
Read more here: https://news.harvard.edu/gazette/story/2026/03/i-think-i-know-how-to-fix-this/
SBGrid's eLife paper received a citation in February from Eric Fischer from Dana-Farber Cancer Institute in Nature Chemical Biology
High-throughput ligand diversification to discover chemical inducers of proximity.
Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.
SBGrid's eLife paper received a citation in February from Elizabeth Wright from University of Wisconsin-Madison in Nature Protocols: Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET.
A protocol for cryogenic 3D correlative focused ion beam milling using an integrated fluorescence light microscope and montage cryo-ET for nonadherent and adherent mammalian cells, as well as primary Drosophila melanogaster neurons.
New Title Alert: mBER-open- is a protein design framework for antibody binder design that leverages structure templates and sequence conditioning in backpropagation-based design through AlphaFold-Multimer.
Learn more here: https://github.com/manifoldbio/mber-open/
SBGrid's eLife paper received a citation in February from James Berger from The Johns Hopkins University School of Medicine in Nature Communications: Supercoiled DNA recognition and cleavage control in topoisomerase VI.
DNA recognition and cleavage control in type II topoisomerases are poorly understood processes. Here, the authors determine cleaved and uncleaved structures of supercoiled DNA-bound topoisomerase VI that reveal how the enzyme activates its cleavage state and prefers to act at deformable substrates.
New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET.
Learn more here: https://mgflast.github.io/easymode/
