Recent PhD graduate KeAndreya Morrison, Ph.D. highlighted a publication from the laboratory of Mihnea Bostina from the University of Otago and colleagues, who uncover the first high-resolution, head-to-tail structural map of a Felixounavirus bacteriophage, revealing how these viruses latch onto bacterial cells and offer new clues for designing next-generation antibacterial therapies.
Read more here: https://medium.com/sbgrid-community-news/mapping-bacteriophages-469dd9761034
For our November software webinar we heard from Hui Wang from UCLA on TomoNet - Automatic Particle Picking of Flexible Lattice-Like Structures for CryoET.
If you missed it, you can watch it on SBGrid's YouTube channel:
Technical Notes: COOT Update: We have added a stand-alone versions of Coot for Linux and for ARM and Intel-based Macs that are available for academic, non-profit, and commercial members to download. These versions will work with MacOS Tahoe and are not dependent on other applications.
Technical Notes: MacOS 26 Tahoe issues--We recommend that users hold off upgrading to MacOS Tahoe since XQuartz-based OpenGL acceleration is partly broken. These issues impact software that rely on XQuartz, such as Coot.
SBGrid's eLife paper received a citation in October from George Phillips Jr. in Journal of Natural Products: Functional and Structural Studies on the Esperamicin Thioesterase and Progress toward Understanding Enediyne Core Biosynthesis.
New Title Alert: Pom- a tool for scaling data analyses in cellular cryoET using comprehensive segmentation.
Learn more here: https://github.com/bionanopatterning/Pom
SBGrid's eLife paper received a citation in October from Jean-Philippe Julien from The Hospital for Sick Children Research Institute in Immunity:
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity.
New Title Alert: OpenEye Academic Package- tools to help design potent and selective bioactive molecules.
Learn more here: https://www.eyesopen.com/
SBGrid's eLife paper received a citation in October from Kevin Campbell from University of Iowa in Nature Magazine: LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan.
LARGE1 glycosyltransferase synthesizes matriglycan (xylose-glucuronate)n on dystroglycan, and short matriglycan can cause neuromuscular disorders. Authors show that LARGE1 processively polymerizes matriglycan of defined length on prodystroglycan.
New Title Alert: nvMolKit- is a CUDA-backed Python library for accelerating common RDKit molecular operations through batch-oriented GPU processing.
Learn more here: https://nvidia-digital-bio.github.io/nvMolKit/#
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