Javier Díaz-NidoJun 17, 2023

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health

https://www.nature.com/articles/s41591-023-02380-x

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease - Nature Medicine

Cross-sectional and longitudinal analyses of tau pathology in preclinical Alzheimer’s disease reveal that tau tangles accumulate as a function of amyloid-β burden only in individuals positive for an astrocyte reactivity biomarker.

Nature
Javier Díaz-NidoJun 12, 2023

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #Neuroimmunology #Neuroimmune #ReactiveAstrocytes #Astrocytes #Glia #Alzheimer #Parkinson #Biomedicine #Health

https://www.nature.com/articles/s41582-023-00822-1

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration - Nature Reviews Neurology

Astrocytes are essential for neuronal survival and function in the CNS but, under pathological conditions, they can adopt potentially harmful reactive states. This Review highlights how ‘omics’ technologies can enable the functional characterization of defined reactive astrocyte states in various pathological scenarios.

Nature