Ketika Setiap Benturan Meninggalkan Bekas: Memahami Chronic Traumatic Encephalopathy
Chronic traumatic encephalopathy (CTE) adalah gangguan neurodegeneratif yang terjadi akibat cedera otak berulang, sering dijumpai pada atlet olahraga kontak. Gejala meliputi gangguan suasana hati, perilaku, dan kognisi. Diagnosis hanya dapat dipastikan setelah kematian. Pencegahan melalui pengurangan benturan kepala adalah satu-satunya langkah yang efektif saat ini.
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
Aβ was associated with increased plasma phosphorylated tau only in individuals positive for astrocyte reactivity (Ast+).
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Neuroinflammation #BetaAmyloid #AmyloidPlaques #Tau #NeurofibrillaryTangles #ReactiveAstrocytes #Astrocytes #Glia #GFAP #Biomarker #Alzheimer #Biomedicine #Health
Cross-sectional and longitudinal analyses of tau pathology in preclinical Alzheimer’s disease reveal that tau tangles accumulate as a function of amyloid-β burden only in individuals positive for an astrocyte reactivity biomarker.
Head-to-head comparison between multiple #PlasmaBiomarkers and neuropathological measures of #AmyloidPlaques and #NeurofibrillaryTangles.
By G. Salvado, O. Hansson & colleagues at Lund University
🗞️ Read #openaccess: https://doi.org/10.15252/emmm.202217123
Bhyllabus l'énigme
Javier Díaz-Nido
EMBO Mol. Medicine