Amelia Cervera 🧬A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function.
Deciphering disordered regions controlling mRNA decay in high-throughput.
#IntrinsicallyDisorderedRegions #IDRs #mRNADecay #RNABindingProteins #RBPs #BuddingYeast
PLOS BiologyCELF family #RNAbindingProteins in #myogenesis. This study shows that #Drosophila Bruno1/CELF promotes a transition to mature splice isoforms, needed for myofibrillogenesis and balanced growth in #sarcomere length & width in flight muscles #PLOSBiology https://plos.io/3QqPtxY
Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly Drosophila flight muscles
The CELF family of RNA binding proteins are important regulators of RNA processing during myogenesis. This study shows that the Drosophila homolog Bruno1 promotes a transition to mature spliceD isoforms, which is necessary for myofibrillogenesis and balanced growth in sarcomere length and width in flight muscles.
An animal’s capacity to thrive hinges on the nervous system translating environmental information into physiological responses. @ananya716 @scientistmomEB &co identify a post-transcriptional mechanism whereby ADAR #RNAbindingProteins regulate the key transcription factor PQM-1 in the #Celegans #NervousSystem to promote survival in low oxygen. #Hypoxia #RBPs #PLOSBiology https://plos.io/3Pxqs2X
ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia
An animal’s capacity to thrive hinges on the nervous system translating environmental information into physiological responses. This study identifies a post-transcriptional mechanism whereby ADAR RNA binding proteins regulate the key transcriptional effector PQM-1 in the C. elegans nervous system to promote survival in low oxygen.