PLOS BiologyCELF family #RNAbindingProteins in #myogenesis. This study shows that #Drosophila Bruno1/CELF promotes a transition to mature splice isoforms, needed for myofibrillogenesis and balanced growth in #sarcomere length & width in flight muscles #PLOSBiology https://plos.io/3QqPtxY
Bruno 1/CELF regulates splicing and cytoskeleton dynamics to ensure correct sarcomere assembly Drosophila flight muscles
The CELF family of RNA binding proteins are important regulators of RNA processing during myogenesis. This study shows that the Drosophila homolog Bruno1 promotes a transition to mature spliceD isoforms, which is necessary for myofibrillogenesis and balanced growth in sarcomere length and width in flight muscles.
Barefield Lab