The intricate mechanisms of epigenetic silencing

Epigenetic silencing, which involves the suppression of gene activity, is a fascinating and increasingly influential branch of biological sciences. It allows cells to remember and maintain specific gene expression patterns throughout development and respond to environmental cues such as winter cold in the case of vernalization in plants.

Phys.org

Development of a potent EED-targeted #PRC2 degrader, UNC7700, highly effective after 24 h in a diffuse large B-cell lymphoma DB cell line:

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components https://pubs.acs.org/doi/10.1021/acschembio.2c00804

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473
#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296