CellBioNewsMay 2, 2024

Understanding cellular #transcription responses to #oxygen deprivation.

#hypoxia #BRD4 #CDK9

https://phys.org/news/2024-05-cellular-transcription-responses-oxygen-deprivation.html

Understanding cellular transcription responses to oxygen deprivation

A multiprotein complex is essential for regulating cellular responses to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.

Phys.org
The EMBO JournalSep 25, 2023
#IκB kinase-alpha #IKK coordinates #BRD4 and #JAK/STAT signaling to subvert DNA damage-based anti-cancer therapy
Lluis Espinosa and coworkers
https://www.embopress.org/doi/full/10.15252/embj.2023114719
The EMBO JournalFeb 3, 2023
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473
Show threadGunning GroupDec 28, 2022
Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to other target proteins, such as those lacking accessible lysines or for which #ubiquitination is slow or inefficient.
Radek NowakDec 8, 2022
Crabtree and Gray labs introduce #TCIPs! Demonstrating that chemical induced proximity between transcription factor #BCL6 and #BRD4, activates downstream #BCL6 target gene expression and results in potent apoptosis. Go go marvels of #inducedproximity! https://www.biorxiv.org/content/10.1101/2022.12.04.517548v1