PLOS BiologyNov 11, 2024
How do DRN & WUS upregulate CLV3 transcription in #plant shoot #ApicalMeristem? This study shows that DRN interferes with WUS dimerization & #ChromatinRemodeling to activate CLV3 transcription, so helping to maintain the shoot stem cell pool #PLOSBiology https://plos.io/3AyF1je
DRN facilitates WUS transcriptional regulatory activity by chromatin remodeling to regulate shoot stem cell homeostasis in Arabidopsis

DRN and WUS are known to upregulate the transcription of CLV3 in the shoot apical meristem of Arabidopsis, but how remains unclear. In this study, DRN is shown to interfere with WUS dimerization and chromatin remodeling to activate CLV3 transcription, thus contributing to the maintenance of the shoot stem cell pool.

StructBiolCommunicationsJun 25, 2024
A #cryoem model of the RSF–NCP complex reveals distinct binding characteristics compared with the SNF2h–NCP complex and biochemical analyses indicate that RSF possesses unique chromatin-remodeling properties #ChromatinRemodeling #RSF #Nucleosome https://t.co/ZP6ZglquKq
Cryo-EM structure and functional analysis of the chromatin remodeler RSF

RSF1 changes the chromatin-remodeling mode of SNF2h. The RSF complex does not have a nucleosome-recentering capacity and a `critical distance' exists during the action of RSF in vitro; this distance is about 24 base pairs. The RSF complex loosens parts of the nucleosome DNA and undergoes conformational change on linker DNA stimulation.

Acta Crystallographica Section F