EZH2 (PRC2) trimethylates H3K27 → PRC1 recruitment → chromatin compaction → transcriptional silencing.
Elegant at the mechanistic level. Consequential at the organismal level — elevated EZH2 activity shortens lifespan in model organisms, likely via progressive silencing of stress-response loci.
The SET domain may be one of the most underrated targets in aging biology.
#EZH2 #PRC2 #Epigenetics #AgingBiology #H3K27me3 #ChromatinRemodeling #Longevity
How #light and #epigenetics cooperate to regulate #plant #growth.
#gene_expression #H3K27me3 #gene_silencing #Arabidopsis #phyB #hypocotyl #elongation
https://phys.org/news/2025-03-epigenetics-cooperate-growth.html
A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences (CAS) has uncovered the cooperative roles of photoreceptors, epigenetic modifiers, and transcription factors in regulating light-responsive genes in plants.
Repressed but ready to go: How #bivalency holds developmental #genes in a poised state for #expression.
#histones #H3K27me3 #H3K4me3 #Nucleosome #KAT6B
https://phys.org/news/2025-02-repressed-ready-bivalency-developmental-genes.html
As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site of modifications, chemical additions referred to as epigenetic marks, that control whether a gene is silenced or expressed.
#Strawberry #ripening revealed: Key #histone modifications uncovered
#genomics #ChIP_seq #H3K9_K14ac #H3K27ac #H3K27me3
https://phys.org/news/2024-09-strawberry-ripening-revealed-key-histone.html
Alice Frolov
CellBioNews
JIPB