earthlingAn osteocyte is the most abundant cell in mature bone. Here’s one in a 3D biomimetic hydrogel system.
Photograph: Shiva Muthuswamy/AIBN
shahfa“Bone mineral organization at the mesoscale: A review of mineral ellipsoids in bone and at bone interfaces”
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doi.org/10.1016/j.ac...
#bone #biomaterials #science #microscopy #electronmicroscopy #bioimaging #imaging #osteocyte #collagen #apatite #science #engineering #biology #physics
https://doi.org/10.1016/j.actbio.2022.02.024
Furqan Shah“Bone mineral organization at the mesoscale: A review of mineral ellipsoids in bone and at bone interfaces”
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https://doi.org/10.1016/j.actbio.2022.02.024
#bone #biomaterials #science #microscopy #electronmicroscopy #bioimaging #imaging #osteocyte #collagen #apatite #science #engineering #biology #physics
🦴🩻🔬🧪 The complex hierarchical structure of bone, where smaller building blocks form progressively larger structures.
Full description in ALT text.
https://doi.org/10.1016/j.actbio.2018.11.018
#bone #osteocyte #biomaterials #osteology #biology #materialsscience #structuralbiology #orthopaedics #microscopy #bioimaging #health #healthcare #science
PLOS BiologyCell-to-cell #mitochondrial transfer within the #osteocyte dendritic network regulates #bone tissue homeostasis, but how? This study shows that osteocytes release ADP under stress conditions, triggering mitochondrial transfer #PLOSBiology https://plos.io/3MdO2Ao
Adenosine diphosphate released from stressed cells triggers mitochondrial transfer to achieve tissue homeostasis
Cell-to-cell mitochondrial transfer within the osteocyte dendritic network regulates bone tissue homeostasis, but the underlying mechanisms remain unknown. This study show that osteocytes release ADP under stress conditions, triggering mitochondrial transfer to achieve tissue homeostasis.
🧪🔬🦴💠 50 years of scanning electron microscopy of bone—a comprehensive overview of the important discoveries made and insights gained into bone material properties in health, disease, and taphonomy
https://www.nature.com/articles/s41413-019-0053-z
#bone #biomineralization #biology #osteocyte #collagen #apatite #mineral #science #electronmicroscopy #microscopy #imaging #biomaterials
50 years of scanning electron microscopy of bone—a comprehensive overview of the important discoveries made and insights gained into bone material properties in health, disease, and taphonomy - Bone Research
Bone is an architecturally complex system that constantly undergoes structural and functional optimisation through renewal and repair. The scanning electron microscope (SEM) is among the most frequently used instruments for examining bone. It offers the key advantage of very high spatial resolution coupled with a large depth of field and wide field of view. Interactions between incident electrons and atoms on the sample surface generate backscattered electrons, secondary electrons, and various other signals including X-rays that relay compositional and topographical information. Through selective removal or preservation of specific tissue components (organic, inorganic, cellular, vascular), their individual contribution(s) to the overall functional competence can be elucidated. With few restrictions on sample geometry and a variety of applicable sample-processing routes, a given sample may be conveniently adapted for multiple analytical methods. While a conventional SEM operates at high vacuum conditions that demand clean, dry, and electrically conductive samples, non-conductive materials (e.g., bone) can be imaged without significant modification from the natural state using an environmental scanning electron microscope. This review highlights important insights gained into bone microstructure and pathophysiology, bone response to implanted biomaterials, elemental analysis, SEM in paleoarchaeology, 3D imaging using focused ion beam techniques, correlative microscopy and in situ experiments. The capacity to image seamlessly across multiple length scales within the meso-micro-nano-continuum, the SEM lends itself to many unique and diverse applications, which attest to the versatility and user-friendly nature of this instrument for studying bone. Significant technological developments are anticipated for analysing bone using the SEM.
🧪🔬🦴💠 Transformation of bone mineral morphology: From discrete marquise-shaped motifs to a continuous interwoven mesh
https://doi.org/10.1016/j.bonr.2020.100283
#bone #biomineralization #biology #osteocyte #collagen #apatite #mineral #science #electronmicroscopy #Ramanspectroscopy #imaging
🦴🩻🔬🧪 50 years of scanning electron #microscopy of #bone—a comprehensive overview of the important discoveries made and insights gained into bone material properties in #health, #disease, and #taphonomy
https://www.nature.com/articles/s41413-019-0053-z
#imaging #microscopy #biomaterials #osteocyte #biomineralization #science #biology #osteology #materialsscience #materials
50 years of scanning electron microscopy of bone—a comprehensive overview of the important discoveries made and insights gained into bone material properties in health, disease, and taphonomy - Bone Research
Bone is an architecturally complex system that constantly undergoes structural and functional optimisation through renewal and repair. The scanning electron microscope (SEM) is among the most frequently used instruments for examining bone. It offers the key advantage of very high spatial resolution coupled with a large depth of field and wide field of view. Interactions between incident electrons and atoms on the sample surface generate backscattered electrons, secondary electrons, and various other signals including X-rays that relay compositional and topographical information. Through selective removal or preservation of specific tissue components (organic, inorganic, cellular, vascular), their individual contribution(s) to the overall functional competence can be elucidated. With few restrictions on sample geometry and a variety of applicable sample-processing routes, a given sample may be conveniently adapted for multiple analytical methods. While a conventional SEM operates at high vacuum conditions that demand clean, dry, and electrically conductive samples, non-conductive materials (e.g., bone) can be imaged without significant modification from the natural state using an environmental scanning electron microscope. This review highlights important insights gained into bone microstructure and pathophysiology, bone response to implanted biomaterials, elemental analysis, SEM in paleoarchaeology, 3D imaging using focused ion beam techniques, correlative microscopy and in situ experiments. The capacity to image seamlessly across multiple length scales within the meso-micro-nano-continuum, the SEM lends itself to many unique and diverse applications, which attest to the versatility and user-friendly nature of this instrument for studying bone. Significant technological developments are anticipated for analysing bone using the SEM.
2/3; #Introduction 🕰️ - My scholarly interests [‼️] include #bone repair #biomaterials, the #osteocyte (a remarkable cell in bone), #osseointegration of implants, #biomineralization. I think #bacteria are fascinating! #electronmicroscopy and #Ramanspectroscopy ftw! #academia #academicchatter #AcademicMastodon #Science #research #phd #mosstodon #icetodon #Fediverse #nature
🦴🔬 Between a rock and a hard place: Organisation of mineralised #collagen fibrils between the surface of a titanium implant and the nearest #osteocyte in human alveolar #bone.
#osseointegration #electronmicroscopy #implantology #osteology #biomineralization #biomaterials
