0 likes, 0 comments - drhowardsmithreports on February 10, 2026: "3D Chip Replaces Animals For Cancer Therapy Testing Cancer research may be entering a new, animal-free era thanks to a novel organ-on-a-chip platform that mimics how human tumors behave. Nanoscientists at the University of Arizona have developed this tumor micro-environment and utilized it for testing the effects of radiation therapy on lung cancer. They report the result in he journal iScience. Their technology is termed ASTEROIDS which is short for Apparatus to Simulate Tumor Environment and Reproduce Organs in an Interactive and Dynamic System. This system mimics the human tumor microenvironment including blood-flow forces, cell-to-cell communication, immune interactions, and mechanical stress. It accurately reproduces how tumors respond to treatment and offers a more human-relevant method for testing cancer therapies. This study focused on lung cancer, but the ASTEROIDS platform can be adapted to any solid tumor. It supports the tenants of the FDA Modernization Act 2.0 which encourages reducing animal testing in favor of human-based lab models. Though used to test radiation therapy in this study, ASTEROIDS will also turbocharge drug development and improve how well lab testing can predict therapy outcomes……someday soon. https://medicalxpress.com/news/2026-01-3d-chip-platform-enables-animal.html https://www.cell.com/iscience/fulltext/S2589-0042(25)02497-6?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S2589004225024976?showall=true #cancer #radiation #testing #animals #organonchip".
Why Cancer Vaccines Fail More Often in Older Patients
Scientists just used an organ‑on‑a‑chip “mini lymph node” to watch how young vs. old immune systems respond to cancer vaccines. The punchline: aging immune cells present antigens worse and activate killer T cells less, even when the vaccine is the same.
That means a lot of preclinical success has been age‑biased from day one.
https://buff.ly/as30NeE
#Cancer #Immunology #OrganOnChip #Aging
Realistic blood vessels built in 10 minutes on a chip? TU Wien’s laser breakthrough could revolutionize drug testing. #Bioengineering #OrganOnChip #FutureOfMedicine
https://geekoo.news/artificial-blood-vessels-at-lightning-speed/
Учёные создали инновационную модель #OrganOnChip для изучения оси кишечник-мозг! 🤯 Эта микрофизиологическая система помогает понять, как нейротоксины из ЖКТ влияют на мозг и способствуют развитию болезней. 🔬💡 #Наука #Медицина #Инновации #ОрганНаЧипе
Подробнее: https://scientia-et-innovatio.blogspot.com/2025/02/organ-on-chip.html
A guide to the organ-on-a-chip | Nature Reviews Methods Primers
#OrganOnChip
as of now its just suited for #pharmacuetical lab tests as a replica
but #bigtech is watching
Organs-on-chips are microfluidic systems containing miniature tissues with the aim of mimicking human physiology for a range of biomedical and therapeutic applications. Leung, de Haan et al. report practical tips to inform design and operational decisions during the implementation of organ-on-a-chip systems.
The project @gutvibrations is developing #OrganOnChip technology for #virology while setting an example in #sustainability ♻️
Discover how the consortium is reducing their carbon footprint with green travel policy and innovative use of online meetings!👉https://cordis.europa.eu/article/id/443092-eu-virology-researchers-lead-the-way-prioritising-sustainability
🐦🔗: https://n.respublicae.eu/EU_HaDEA/status/1649357522229161984
Call for a Junior Professor chair at Aix Marseille University. Supported topic: "innovation to transform modeling of pathologies". Keywords: "organoids, cancer spheroids, organ-on-chip, stem cells, iPSCs". Deadline to apply: May 22, 2023
#PIcall #AMU #organoids #OrganOnChip #stemCells #iPSC #CancerSpheroids
#DevBio
Dear people interested in #organoids #Tcells #Macrophages #Bcells #DendriticCells #MucosalImmunology #microbiome #OrganOnChip #MicroPhysiologicalSystems #IBD #CeliacDisease #iPSCs,
where are you? I want to follow you!
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