I met Matteo Allegretti, as well as discussing the impact of preprints, he explained his research on the nuclear pore complex and why sperm cells do not need as much transport in/out of the nucleus. (4/5)

#Cryotomography #NuclearPoreComplex

https://www.youtube.com/watch?v=42th8kOjs08

spotLights Ep 14: preLights in conversation with Matteo Allegretti

YouTube
Check out our 'First persons' interview with Kerstin Hinterndorfer and Felix Mikus on their joint project establishing an optimised protocol for expansion microscopy in yeast:
https://journals.biologists.com/jcs/article/135/24/jcs260862/286124/First-person-Kerstin-Hinterndorfer-and-Felix-Mikus
#cellbiology #expansionmicroscopy #U-ExM #S.pombe #S.cerevisiae #microtubules #nuclearporecomplex
First person – Kerstin Hinterndorfer and Felix Mikus

ABSTRACT. First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Kerstin Hinterndorfer and Felix Mikus are co-first authors on ‘ Ultrastructure expansion microscopy reveals the cellular architecture of budding and fission yeast’, published in JCS. Kerstin is a PhD student in the lab of Robbie Loewith at University of Geneva, Switzerland, working on TOR signaling and expansion microscopy in yeast. Felix is a predoctoral fellow in the lab of Dr Gautam Dey in Heidelberg, Germany, investigating how nuclear pore complex dynamics regulate nuclear remodeling and proteostasis in closed and semi-closed mitosis.

The Company of Biologists
Supercomputing simulations help reveal traffic mechanisms through the nuclear pore complex

Students learn about the nucleus in ninth grade biology—it's the inner sanctum of biological cells, where the genome resides with the blueprints for cells to make proteins that are the building-blocks of life. Guarding those valuable blueprints is a dual-layer membrane, which not only protects, but also filters important molecules that regulate cellular functions.

Phys.org