It's a good thing Covid doesn't affect kids, because if it did, that could have dire and unpredictable consequences given the role Neuropilin-1 plays in the developing brain.
https://www.nature.com/articles/s41467-021-22532-2
#Covid
#NRP1
Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor - Nature Communications
Oligodendrocyte precursor cell (OPC) proliferation and differentiation is greater in white matter than gray matter. Here, the authors show regulation of OPC proliferation in white matter involved trans-activation of PDGFRα on OPCs via Nrp1 expressed by adjacent microglia.
@jonaskunst
Re: #Temelimab (Anti HERV-env)
#PathogenicCoronaviruses are known for the severe amount of #Complement component activation provoked. In keeping with that, surface Complement Regulatory Protein #CD46 inducts HERV-Env via C3b attached to SCRs 2-4. Interestingly enough, the Split Complement products produced via CD46 mediated inactivation of #C3b and #C4b are #NRP1 ligands.
CD46 & HERV-Env: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291489/
NRP1: https://pubmed.ncbi.nlm.nih.gov/31572401/
Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement
The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS). In particular, the expression of the envelope protein (Env) from the multiple sclerosis-associated ...
J.H.Noyes