J.H.NoyesNov 28, 2022

This #acubin stuff is really interesting, understudied tho. It gives the appearance of being active in the proteomic space where #PathogenicCoronaviruses like #SARS2CoV2 deal injury. It is naturally occuring in #eyebright.

https://pubmed.ncbi.nlm.nih.gov/23612013/

Aucubin, a naturally occurring iridoid glycoside inhibits TNF-α-induced inflammatory responses through suppression of NF-κB activation in 3T3-L1 adipocytes - PubMed

Obesity is closely associated with a state of chronic, low-grade inflammation characterized by abnormal cytokine production and activation of inflammatory signaling pathways in adipose tissue. Tumor necrosis factor (TNF)-α is chronically elevated in adipose tissues of obese rodents and humans. Incre …

PubMed
Show threadJ.H.NoyesNov 23, 2022

@jonaskunst

Re: #Temelimab (Anti HERV-env)

#PathogenicCoronaviruses are known for the severe amount of #Complement component activation provoked. In keeping with that, surface Complement Regulatory Protein #CD46 inducts HERV-Env via C3b attached to SCRs 2-4. Interestingly enough, the Split Complement products produced via CD46 mediated inactivation of #C3b and #C4b are #NRP1 ligands.

CD46 & HERV-Env: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291489/

NRP1: https://pubmed.ncbi.nlm.nih.gov/31572401/

Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement

The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS). In particular, the expression of the envelope protein (Env) from the multiple sclerosis-associated ...

PubMed Central (PMC)