Mastodawn

J.H.Noyes Nov 23, 2022

Re: #Temelimab (Anti HERV-env)

#PathogenicCoronaviruses are known for the severe amount of #Complement component activation provoked. In keeping with that, surface Complement Regulatory Protein #CD46 inducts HERV-Env via C3b attached to SCRs 2-4. Interestingly enough, the Split Complement products produced via CD46 mediated inactivation of #C3b and #C4b are #NRP1 ligands.

CD46 & HERV-Env: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291489/

NRP1: https://pubmed.ncbi.nlm.nih.gov/31572401/

Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement

The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS). In particular, the expression of the envelope protein (Env) from the multiple sclerosis-associated ...

PubMed Central (PMC)