RE: https://mstdn.ca/@ducky/116780751613938974

Some notable things from @ducky 's weekly roundup https://covidbc.webfoot.com/2026/06/19/2026-06-19-general/ :

for children over 8 years old, ones with a history of reinfection were almost ten times more likely to get Long COVID than those who did not. For children under 8 y/o, reinfection doubled the risk, and boys were almost five times more likely to get Long COVID than girls.

and

that one dose of an mRNA COVID-19 vaccine reduced the likelihood of developing Long COVID by 63%.

More evidence for metformin's effectiveness against LC, and first I've heard of sodium-glucose cotransporter-2 inhibitors (SGLT2i) having an impact as well.

#SARSCoV2 #COVID19 #COVID #LongCOVID #metformin

Enttäuschender Medizinjournalismus

Medizinportale berichten von einer Studie, laut der bei #COVID19 eingenommenes #Metformin das Risiko, an #LongCovid halbiere.

Tatsächlich zeigte die Studie, die einige Probleme hat, leider keine signifikante Wirkung. Lediglich ein sekundärer Endpunkt ("klinisch diagnostiziertes Long Covid") war positiv, allerdings mit einem enorm hohen Konfidenzintervall - risk ratio 0.495 (95% CrI 0.155 to 0.995).

Vielleicht werden zukünftige Studien ein Wirksamkeit von Metformin belegen. Hinweise dafür gibt es ja einige. Aber wenn Studienergebnisse so selektiv wiedergegeben werden, ohne auf den Unterschied primärer vs sekundärer Endpunkt oder auf Konfidenzintervalle einzugehen, dann ist das Ahnungslosigkeit oder Propaganda.

Die Studie:
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciag335/8702406?login=false

Started taking #Metformin last week. No appetite and I hadn’t noticed.

I ended up throwing food away as it was out of date.

That was the only sign I had that anything was different.

RE: https://disabled.social/@tomkindlon/116717085328668673

This study used a self-report for primary outcome, and found

Some secondary outcomes did have high posterior probabilities of efficacy, including 0.98 for symptom burden on day 120 and 0.96 for clinician diagnosis of long COVID on day 180.

So I think the real result from this study is "the study was underpowered" and not "metformin doesn't work for LC" because their results also cannot be distinguished from "metformin during acute COVID-19 reduces Long COVID rate by a quarter"

People who got Metformin:

• were 24% less likely to self-report Long COVID at 180 days
• were 22% less likely to be clinically diagnosed with Long COVID at 180 days

and consider their conclusion:

Metformin did not exceed the primary outcome threshold for declaring efficacy for reducing PASC. The posterior probability of efficacy for metformin was high for preventing a clinician diagnosis of long COVID and for symptom burden, consistent with prior clinical trial and observational data. No safety concerns occurred in this trial of metformin in low-risk adults. While a low event rate makes it challenging to evaluate therapeutics

https://dx.doi.org/10.1093/cid/ciag335

#COVID #COVID19 #SARSCoV2 #LongCOVID #Metformin #PASC

Metformin, the diabetes drug that has been thought to suppress glucose production in the liver, instead inhibits mitochondria in the gut, causing the gut to increase its consumption (and breakdown) of glucose.

Summary: https://refractor.io/diabetes/metformin-gut-health-benefits/

Original paper: https://www.nature.com/articles/s42255-026-01530-y

#Science #Metformin #Diabetes #Metabolism

Metformin Raises Exercise-Associated Metabolite Lac-Phe in Prostate Cancer Patients on Hormone Therapy

📰 Original title: Diabetes Drug, Metformin, May Echo the Benefits of Exercise in Prostate Cancer Care

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

View full AI summary: https://killbait.com/en/metformin-raises-exercise-associated-metabolite-lac-phe-in-prostate-cancer-patients-on-hormone-therapy/?redirpost=e646279c-9669-4f2b-83ba-fba5b2643fac

#health #metformin #prostate...

Metformin Raises Exercise-Associated Metabolite Lac-Phe in Prostate Cancer Patients on Hormone Therapy

📰 Original title: Diabetes Drug, Metformin, May Echo the Benefits of Exercise in Prostate Cancer Care

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

View full AI summary: https://killbait.com/en/metformin-raises-exercise-associated-metabolite-lac-phe-in-prostate-cancer-patients-on-hormone-therapy/?redirpost=e646279c-9669-4f2b-83ba-fba5b2643fac

#health #metformin #prostate...

After 60+ years, the common diabetes drug metformin has been found to unexpectedly affect the brain.
A new study shows it targets the protein Rap1 in the ventromedial hypothalamus, activating SF1 neurons to help lower blood glucose — and it works at much lower concentrations in the brain than in the body.
Promising findings that could lead to better treatments for glucose control and possibly brain protection.

#Metformin #Diabetes #BrainHealth #MedicalResearch #Prediabetes

https://www.sciencealert.com/after-60-years-diabetes-drug-revealed-to-unexpectedly-affect-the-brain