Show threadAnti. 🐘4d ago

· New study linked ongoing endothelial dysfunction in people with #LongCOVID with neuropsychiatric symptoms
[https://www.sciencedirect.com/science/article/pii/S2666354626000803?via%3Dihub#sec11]
· Small observational study from Jamaica found nearly half of pediatric participants met the diagnostic criteria for Long COVID
[https://journals.lww.com/pidj/fulltext/9900/long_covid_19_in_hospitalized_and_ambulatory.1720.aspx]
· Long COVID clinical trial investigating the cancer drug (sirolimus) rapamycin was recently updated to have an open label extension
[https://www.als-mnd.org/support-for-pals-cals/research/open-label-extension/]

https://thesicktimes.org/2026/05/12/research-updates-may-12/

#ResearchUpdates #COVID

Show threadAnti. 🐘May 6

· A specific formula of probiotics was found to improve fatigue and other symptoms in people with #LongCOVID
[https://aga-fileuploader-bucket.s3.us-east-2.amazonaws.com/389%20Probiotics%20and%20Long%20COVID%20FNL.pdf]
· A new review on Long COVID concluded that addressing the heterogeneity of the disease is crucial for the future development of treatments
[https://www.nature.com/articles/s43856-025-01300-z]
· Another review in Frontiers evaluated PEM
[https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1774310/full]

https://thesicktimes.org/2026/05/05/research-updates-may-5/

#ResearchUpdates #COVID #PandemicIsNotOver

Show threadAnti. 🐘Apr 29

· Written memorials of over 500 people who had myalgic encephalomyelitis (#ME) were analyzed in a new study in PLoS One
[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0343374]
· New study in Pediatric Research found microclots in the blood of children with #LongCOVID
[https://www.nature.com/articles/s41390-026-05024-1]
· A third cancer drug is being trialed for Long COVID
[https://clinicaltrials.gov/study/NCT07388550]

https://thesicktimes.org/2026/04/28/research-updates-april-28/

#ResearchUpdates #TheSickTimes

Investigating the ME/CFS experience through qualitative analysis of memorial entries

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an impairing chronic condition characterized by exhaustion and worsening symptoms following exertion, often accompanied by pain, sleep issues, and cognitive issues. Historically, ME/CFS was not considered to be linked to mortality, however, more recent studies have questioned this assumption. The National Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Foundation maintains a memorial list consisting of deceased individuals who had ME/CFS. This secondary qualitative thematic analysis analyzed 505 entries on the National CFIDS Foundation memorial list, inductively developing a codebook from the publicly available memorial records. Two coders independently coded each entry before meeting to develop themes that incorporated the understanding of each coder. Themes emerged within four societal levels: systemic neglect and institutional failure; clinical neglect and failures; social disconnection and advocacy; and personal burden and quality of life. Describing systemic neglect and institutional failure, entries recounted a lack of acknowledgement by health, insurance, and disability authorities, as well as a lack of investment in research and treatment of ME/CFS at the federal level. Negative healthcare experiences included misdiagnosis and misattribution of symptoms, dismissal, inadequate knowledge and experience with treating ME/CFS, and the recommendation of unhelpful treatments. The disbelief and misattribution by acquaintances described in the entries contributed to feelings of social isolation, leading some to turn to advocacy work and support groups. Entries also described the individual impact of the condition, including functional impairments, the impact of symptoms, management strategies, financial stress, and mental health symptoms. Some deaths were directly and indirectly attributed to ME/CFS by individuals with ME/CFS and their acquaintances. This analysis provides a glimpse of the lived experience as well as death of individuals with ME/CFS through the lens of acquaintances of the deceased, emphasizing the substantial impact of the condition.

Show threadAnti. 🐘Apr 22

· A new RECOVER study found that #LongCOVID significantly impacts the development of children with the disease
[https://www.academicpedsjnl.net/article/S1876-2859(26)00096-3/fulltext]
· A recent preprint found that a nasal monoclonal antibody improved Long COVID cognitive dysfunction in mice
[https://www.biorxiv.org/content/10.64898/2026.04.07.716934v2]
· A phase four clinical trial in Toronto, Ontario, will evaluate stellate ganglion blocks (SGB) for Long COVID
[https://clinicaltrials.gov/study/NCT07468604?cond=Dysautonomia&aggFilters=status:not%20rec&viewType=Card&rank=3]

https://thesicktimes.org/2026/04/21/research-updates-april-21/

#ResearchUpdates #TheSickTimes

Show threadAnti. 🐘Apr 15

· A new report found that #LongCOVID may cost OECD international economies over $135 billion per year over the next decade
· Long COVID is associated with an increased risk of cardiovascular disease, a new study in The Lancet found
· A small study identified persistent immune dysregulation and coagulation in people with post-vaccine syndrome (PVS) from COVID-19 vaccines

https://thesicktimes.org/2026/04/14/research-updates-april-14/

#ResearchUpdates #TheSickTimes

Research updates, April 14 - The Sick Times

A new report found that Long COVID may cost OECD international economies over $135 billion per year over the next decade. And even this number may be an undercount, the authors stated.

The Sick Times - Chronicling the Long COVID crisis
Show threadAnti. 🐘Apr 8

· A clinical trial for non-invasive vagal nerve stimulation failed in improving fatigue in #LongCOVID
· A new study in JACC Advances compared two common types of dysautonomia in Long COVID, as well as their overlap
· German health insurance companies will cover four off-label drugs for Long COVID and related diseases

https://thesicktimes.org/2026/04/07/research-updates-april-7/

#ResearchUpdates #COVID #PandemicIsNotOver

Research updates, April 7 - The Sick Times

A clinical trial for non-invasive vagal nerve stimulation failed in improving fatigue in Long COVID. 45 participants used a specific transcutaneous auricular vagus nerve stimulation (taVNS) device, or a sham (placebo), during the four-week trial.

The Sick Times - Chronicling the Long COVID crisis
Show threadAnti. 🐘Apr 1

· Heart failure drug Ivabradine didn't significantly improve symptoms for people with #LongCOVID & #POTS, say preliminary results RECOVER researchers shared at conference
· Another study has found that injecting autoantibodies from people with Long COVID into mice causes “pain-like behavior” in the animals
· Clinical trial testing fibrinolytic enzyme lumbrokinase now offering decentralized option, participants can participate from home

https://thesicktimes.org/2026/03/31/research-updates-march-31/

#ResearchUpdates #TheSickTimes

Research updates, March 31 - The Sick Times

The heart failure drug Ivabradine did not significantly improve symptoms for people with Long COVID and postural orthostatic tachycardia syndrome (POTS), according to preliminary results that RECOVER researchers recently shared at a conference.

The Sick Times - Chronicling the Long Covid crisis
Show threadAnti. 🐘Mar 25

· More than 150,000 deaths from #COVID19 went uncounted in the U.S. in the first two years of the pandemic, a new study in Science Advances finds
· Swiss researchers have found up to 60% of healthcare workers in a medium-size cohort study may have at least one symptom of #LongCOVID
· Small clinical trial recruiting in Orange, CA, to test Percutaneous Electrical Nerve Field Stimulation in children with post-concussion syndrome and LC

https://thesicktimes.org/2026/03/24/research-updates-march-24/

#ResearchUpdates #TheSickTimes

Research updates, March 24 - The Sick Times

More than 150,000 deaths from COVID-19 went uncounted in the U.S. in the first two years of the pandemic, according to a new study in Science Advances. Researchers used machine learning to evaluate death certificates from March 2020 to December 2021, and estimated that 19% more COVID-19 deaths occurred than originally reported.

The Sick Times - Chronicling the Long Covid crisis
Show threadAnti. 🐘Mar 18

· Two recent prevalence studies showed the impact of #LongCOVID on Americans
· A small study shared as a preprint in bioXriv found SARS-C0V-2 spike protein in the gut tissues of people with Long COVID
· Researcher Dianna Arnoux-Whiteman was awarded a $45,000 grant to survey the effects of Long COVID in the Blackfeet Nation

https://thesicktimes.org/2026/03/17/research-updates-march-17/

#ResearchUpdates #TheSickTimes

Research updates, March 17 - The Sick Times

Two recent prevalence studies showed the impact of Long COVID on Americans. The first, an electronic cohort study of over 600,000 active military personnel, found that 42% had at least one symptom more than 30 days after contracting COVID-19.

The Sick Times - Chronicling the Long Covid crisis
Show threadAnti. 🐘Mar 11

· A large retrospective cohort study found significant healthcare cost increases for #LongCOVID over five years
· A South Korean clinical trial evaluated metformin and ursodeoxycholic acid (UDCA) for Long COVID, but didn’t find either effective
· Two recent preprints share additional analysis from clinical trials seeking to address viral persistence

https://thesicktimes.org/2026/03/10/research-updates-march-10/

#ResearchUpdates #COVID

Research updates, March 10 - The Sick Times

A large retrospective cohort study found significant healthcare cost increases for Long COVID over five years. The study was shared as a preprint in medRxiv and included the records of over 143,000 people.

The Sick Times - Chronicling the Long Covid crisis