Brilliant work by #WhiteheadInstitute researchers and collaborators unpacking MECP2’s complex role in Rett syndrome - as both a gene activator and repressor. A powerful step toward more targeted therapies. #RettSyndrome #Neuroscience #Genetics #MECP2 #ScienceMatters #JaenischLab #YoungLab

RE: https://bsky.app/profile/did:plc:376brirdwae4fayb4sd3bzdy/post/3lp5hlxwl722j
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A common parasite could one day deliver drugs to the brain − how scientists are turning ‘Toxoplasma gondii’ from foe into friend

Getting drugs into the brain is a challenge. A new study suggests a brain parasite may be able to help.

The Conversation

Dear #RettSyndrome community and #MeCP2 aficionados. I will give a talk at the 2023 Rett Syndrome Scientific Mtg in Nashville, TN 👉 June 5-7. Thanks to the IRSF and the meeting's scientific committee for the invitation 🙏 More info to come ;-)

https://www.rettsyndrome.org/2023scientificmtg/

2023 IRSF Rett Syndrome Scientific Meeting - International Rett Syndrome Foundation

The IRSF Rett Syndrome Scientific Meeting brings together researchers studying Rett and related fields in academia, industry, and governmental agencies from around the world.

International Rett Syndrome Foundation
FDA approval of trofinetide may spur further drug development for Rett | Spectrum | Autism Research News

The drug, welcomed by patients, might be just the first of many.

Spectrum | Autism Research News
Debut drug for Rett syndrome at edge of approval | Spectrum | Autism Research News

The U.S. Food and Drug Administration plans to make an approval decision on the first-ever drug for girls and women with Rett syndrome by 12 March.

Spectrum | Autism Research News
Going on Trial: Orphan drugs; CBD; bumetanide | Spectrum | Autism Research News

This month’s newsletter takes a close look at the orphan drug program in the United States, several cannabis-based therapies and a secondary analysis of bumetanide, among other new developments in autism-related drug trials.

Spectrum | Autism Research News
Epigenome edits unmute MECP2 in Rett-like neurons | Spectrum | Autism Research News

The approach removes methyl tags from the gene and shields it from other silencing factors without changing the gene itself, raising hopes for a new treatment.

Spectrum | Autism Research News

“Of the 8 women that completed psychological evaluation and the Symptom Checklist 90-R, half were treated for depression prior to the birth of a child with MDS. All 8 women exhibited symptoms of anxiety and for six, anxiety was present prior to the birth of the affected child.”

👉 Yes, studying #MeCP2, #Epigenetics, #RettSyndrome, and #MDS is important.

👉 Yes, studying #anxiety, #depression, and #screening for better drugs is essential.

https://ojrd.biomedcentral.com/articles/10.1186/s13023-022-02278-w

RNA rewrite improves breathing, survival in Rett mice | Spectrum | Autism Research News

The technique involves editing the cellular instructions to make MECP2 protein and partially restores its levels in the brainstem.

Spectrum | Autism Research News
Portrait of a research field: astrocytes in autism | Spectrum | Autism Research News

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

Spectrum | Autism Research News