Gute Pillen – Schlechte PillenSep 11, 2025
Seit gestern ist Heft 5 in diesem Jahr online und auf dem Postweg zu euch🎈Unsere Themen: #Lipoprotein a, #Melatonin, #Grippesaison, #Migräne und vieles mehr. Hier geht´s zu den Artikeln: https://gutepillen-schlechtepillen.de/hefte/jahrgang-2025/nr-5-september-oktober-2025/
Nr. 5 September/Oktober 2025 - Gute Pillen - Schlechte Pillen

Was bedeutet Lipoprotein für die Herzgesundheit? Welche Wirkstoffe können Schlafstörungen verursachen? Und: Wieso versteckt sich Natrium in Brausetabletten?

Gute Pillen - Schlechte Pillen
BodlingMar 30, 2025

It's really worth having your doctor run this blood test for you. Lots of those "surprise" heart attacks you read about among athletes and celebrities -- maybe even your own young family members -- are traced to Lipoprotein (a), aka Lp(a), pronounced "L. P. little a".

https://www.nytimes.com/2025/03/30/health/heart-attack-lpa-protein.html?unlocked_article_code=1.704.h__M.Tf9VfbL6fNBq&smid=url-share

#HeartAttack #Lp(a) #Lipoprotein(a)

Eli Lilly Drug Reduces Mysterious Lp(a) Particle Involved in Heart Attack Risk

The Eli Lilly drug caused a major drop in the blood levels of Lp(a), but further research is needed to show that it will prevent heart attacks and strokes.

The New York Times
Boris TefsenMay 30, 2024

#Lolamicin is a new #antibiotic specifically targeting the Gram-negative LolCDE complex that is involved in #lipoprotein transport.

Great name (lol means fun in Dutch) and I also appreciate this finding because of me working with LolA in the past.

https://www.nature.com/articles/d41586-024-01566-8

‘Smart’ antibiotic can kill deadly bacteria while sparing the microbiome

Compound called lolamicin targets a group of harmful microbes but does not disturb those that live peacefully in the gut.

PLOS BiologyJan 8, 2024
#StaphAureus lipoproteins play unique roles in cellular processes & host interactions. @SchilcherKatrin @Horswill_Lab reveal that #lipoprotein CamS represses toxin production, showing how lipoproteins can affect #virulence & disease outcomes #PLOSBiology https://plos.io/48Of5f3
The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction

Staphylococcus aureus lipoproteins fulfill unique biological roles. Katrin Schilcher and co-workers revealed that the staphylococcal lipoprotein CamS represses toxin production. This discovery sheds light on how a lipoprotein contributes to virulence and shapes disease outcomes.

Matt WillemsenJan 6, 2024
Surprising Study Links 'Good' Cholesterol With Up to 42% Higher Dementia Risk
https://www.sciencealert.com/surprising-study-links-good-cholesterol-with-up-to-42-higher-dementia-risk #GoodCholesterol #Dementia #Risk #HDL #cholesterol #lipoprotein
Surprising Study Links 'Good' Cholesterol With Up to 42% Higher Dementia Risk

When it comes to cholesterol, it's usually sorted into the 'good' kind and the 'bad' kind based on their effects on heart health – but now a new study has shown that the 'good' type of cholesterol could have other health risks attached.

ScienceAlert
The EMBO JournalOct 9, 2023
#Macrophage-derived #insulin antagonist ImpL2 causes #lipoprotein mobilization upon bacterial #infection
Adam Bajgar, Tomas Dolezal and coworkers, University of South Bohemia
https://www.embopress.org/doi/full/10.15252/embj.2023114086
Matt WillemsenSep 2, 2023
A “Silent Killer” With No Treatment – Scientists Develop Game-Changing Drug
A new oral drug, Muvalaplin, successfully lowers Lipoprotein(a) or Lp(a), a genetic form of cholesterol linked to heart attack and stroke, by up to 65%, marking a significant breakthrough as there is currently no approved treatment for high Lp(a) levels.
https://scitechdaily.com/a-silent-killer-with-no-treatment-scientists-develop-game-changing-drug/ #Cholesterol #Drugs #HeartAttack #Muvalaplin #Lipoprotein(a)
A “Silent Killer” With No Treatment – Scientists Develop Game-Changing Drug

A new drug presents the world's first treatment for Lipoprotein(a), a predominantly genetic type of cholesterol that elevates the risk of cardiac arrest or stroke. Professor Stephen Nicholls, Director of the Victorian Heart Institute and Victorian Heart Hospital at Monash University, recently annou

SciTechDaily
Vivek MutalikFeb 4, 2023

Teasing apart the #evolution of #lipoprotein trafficking in gram-negative bacteria reveals a bifunctional LolA | PNAS

https://www.pnas.org/doi/10.1073/pnas.2218473120

Robert West, PhDNov 22, 2022

#Race-Dependent Association of High-Density #Lipoprotein #Cholesterol Levels With Incident #Coronary Artery Disease
https://www.jacc.org/doi/10.1016/j.jacc.2022.09.027
#HDL #CVD #CAD #PM101

From #NIH#NHLBI: STUDY CHALLENGES “GOOD” CHOLESTEROL’S ROLE IN UNIVERSALLY PREDICTING #HEARTDISEASE RISK

Race-Dependent Association of High-Density Lipoprotein Cholesterol Levels With Incident Coronary Artery Disease:

Journal of the American College of Cardiology
DanieDec 25, 2018
HDL Cholesterol: Too Much of a Good Thing? https://squeet.me/display/962c3e10-125c-21e3-e660-410955943857
HDL Cholesterol: Too Much of a Good Thing?

An ample supply of HDL cholesterol in blood serum has long been linked to protection against coronary heart disease and stroke, so what could be bad? A seri...