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Komplementer Oktatóközpont🍩 Súlyszabályozás – A beled kívánja a cukrot, nem te! A baktériumok harca a cukorért! ⚖️
👉 Különösen fontos: A diszbiózis hatására a káros baktériumok erősebben vágynak a cukorra, és ezt az üzenetet közvetítik az agynak!
Üzenet: A diéta és a testsúly elleni küzdelem nemcsak az akaraterődön múlik, hanem azon is, hogy melyik baktériumot eteted!
#elhízás #ghrelin #leptin #cravings #diéta
#aradiágnes #komplementeroktatóközpont #természetgyógyászoktatás #természetgyógyászat #egészség
mythologyandhistory1 more day until the first #Nobel Prize for #PHYSIOLOGY or #MEDICINE will be announced!
My bet is on Jeffrey M. Friedman & Rudolph Leibel for their discovery of #leptin, a hormone that has a role in #obesity.
(I would LIKE the prize to go to the team that developed the endobronchial valve, a minimally invasive device that is used to divert air from diseased portions of the lung to healthier ones. It's used by COPD & tuberculosis patients.)
What is everyone else's #prediction???
Universität Leipzig#Leptin ist ein zentrales Hormon bei der Regulation von Hunger und Sättigung. Eine große internationale Studie mit federführender Beteiligung der #UniLeipzig hat erstmals umfassende Referenzwerte für Leptin über alle Altersgruppen und Gewichtsklassen hinweg erstellt.
Die Ergebnisse und das daraus resultierende Online-Tool tragen zur Weiterentwicklung in der personalisierten Medizin bei, insbesondere zur Bewertung von Stoffwechselgesundheit und #Adipositas.
grumbledookWe need to redefine the term #brainfarts .
https://www.nature.com/articles/s42255-025-01280-3
"Our results showed that these brain interventions significantly changed the gut microbiota in an anatomical and short-term (2–4 h) fashion."
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice - Nature Metabolism
Toledo et al. show that metabolic hormones acting in the hypothalamus, along with direct manipulation of hypothalamic neurons, can drive remodelling of microbial communities in the gut within short periods of time.
Howard Smith MD, AMWhy Women Experience More Pain Than Men: When a woman and a man both sustain injuries to their pain-generating nerves, only the woman produces a unique hormone that intensifies that pain. #pain #men #women #neuropathic #pannexin1 #leptin #vegf
https://www.instagram.com/drhowardsmithreports/reel/DH9OeHitn2J/
https://www.instagram.com/drhowardsmithreports/reel/DH9OeHitn2J/
Howard G. Smith MD, AM on Instagram: "Why Women Experience More Pain Than Men When a woman and a man both sustain injuries to their pain-generating nerves, only the woman produces a unique hormone that intensifies that pain. University of Calgary researchers report this discovery in the journal Neuron. Their study was in part triggered by a 2019 Canadian Pain Task Force report that verified the higher incidence of chronic pain in females versus males of every age including children. Utilizing rodent animal models, their data showed that neuropathic pain, pain out of proportion to a harmful stimulus, is mediated by pannexin1 microglial and T cells channels in both men and women. In females, nerve injury leads to activation of T cells and the hormone leptin which potentiates pain. In males, the injury leads to release of a vascular endothelial growth factor from microglial cells and this VEGF blocks pain transmission. Discovery of this gender-dependent generation of chronic pain could well lead to strategies for blocking pannexin1 channels for both males and females as well as neutralizing the effects of leptin-magnified pain in females. https://www.cell.com/neuron/fulltext/S0896-6273(25)00009-1?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S0896627325000091?showall=true https://www.sciencedaily.com/releases/2025/03/250317160418.htm #pain #men #women #neuropathic #pannexin1 #leptin #vegf"
0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Why Women Experience More Pain Than Men When a woman and a man both sustain injuries to their pain-generating nerves, only the woman produces a unique hormone that intensifies that pain. University of Calgary researchers report this discovery in the journal Neuron. Their study was in part triggered by a 2019 Canadian Pain Task Force report that verified the higher incidence of chronic pain in females versus males of every age including children. Utilizing rodent animal models, their data showed that neuropathic pain, pain out of proportion to a harmful stimulus, is mediated by pannexin1 microglial and T cells channels in both men and women. In females, nerve injury leads to activation of T cells and the hormone leptin which potentiates pain. In males, the injury leads to release of a vascular endothelial growth factor from microglial cells and this VEGF blocks pain transmission. Discovery of this gender-dependent generation of chronic pain could well lead to strategies for blocking pannexin1 channels for both males and females as well as neutralizing the effects of leptin-magnified pain in females. https://www.cell.com/neuron/fulltext/S0896-6273(25)00009-1?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S0896627325000091?showall=true https://www.sciencedaily.com/releases/2025/03/250317160418.htm #pain #men #women #neuropathic #pannexin1 #leptin #vegf".
Cytology and GeneticsHow Effective are leptin Gene Polymorphisms and Methylation during the Course of Multiple Myeloma? - #multiplemyeloma #leptin #methylation #diagnosis #survival #myeloma - https://link.springer.com/article/10.3103/S0095452724040091
How Effective are leptin Gene Polymorphisms and Methylation during the Course of Multiple Myeloma? - Cytology and Genetics
Abstract Leptin is mainly produced from adipose tissue and released into the circulation. Circulating leptin binds to the leptin receptor (LEPR) in the brain, which activates signaling pathways that inhibit feeding and promote calorie expenditure. The leptin receptor (LEPR, also known as Ob-R) gene is located at chromosome 1p31. DNA methylation consists of addition a methyl group at position 5′ of the pyrimidine ring of the cytosines upstream of a guanine (dinucleotide CpG) catalyzed by DNA methyltransferases. Methylation of cytosine in CpG sites is an important epigenetic modification way that could suppress the gene expression. This study was conducted to reveal the role of leptin (-2548 G/A, rs7799039) and LEPR (-668 A/G, rs113711) gene polymorphisms in patients diagnosed with multiple myeloma (MM). Patients who were diagnosed with MM and followed-up in our clinic between January 2010 and January 2022 were included in the study. The genotypes of the leptin (-2548 G/A, rs7799039) and LEPR (-668 A/G, rs113711) genes were statistically compared between patients and healthy controls. Additionally, the statistically significant effects of these genotypes on survival were examined. In addition, the methylation status of the patients was compared to the healthy control group, and the effect on survival was evaluated. A total of 300 patients diagnosed with MM and 170 individuals to form a healthy control group were included in this study. In the statistical analysis performed to investigate the effect of leptin and LEPR gene polymorphisms on disease susceptibility, GA and AA genotypes of the leptin gene were found to be significantly higher in the patient group compared to healthy controls. In the statistical analysis for -31 NT and -51 NT methylation of the leptin gene, -51 NT methylation was found to be significantly higher in healthy controls (p = 0.002). In the survival analysis, progression-free survival (PFS) of patients with GG genotype of the LEPR gene was found to be significantly shorter compared to others, there was no effect on the overall survival. In the multivariate analysis, it was revealed that the PFS of patients with GG genotype of the LEPR gene was 2.02 times shorter compared to others (RR: 2.017; CI: 1.191–3.418, p = 0.009). MM and leptin polymorphisms have significant features in terms of both disease susceptibility and treatment response.
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Det är otroligt lätt att hitta på saker som låter som fakta. Det pågår konstant mängder av olika processer i kroppen där det mesta fungerar med så kallad redundans. Det innebär att det finns flera sätt för kroppen att uppnå samma sak. Om du försöker påverka en process genom att göra en sak så […]
Performance Psychology Blog✔️ Harness Leptin for Healthy Weight: Understand appetite regulation, metabolism, leptin resistance. Balanced diet, exercise, sleep, stress management. #Leptin #WeightManagement #AppetiteRegulation #Metabolism
✔️ Harness Leptin for Healthy Weight: Understand appetite regulation, metabolism, leptin resistance. Balanced diet, exercise, sleep, stress management. #Leptin #WeightManagement #AppetiteRegulation #Metabolism