Neutralizing #antibody #evasion of #SARS-CoV-2 #JN1 derivatives #KP3, #KP311, #LB1, and #XEC

Source: BioRxIV, AbstractThe emergence of SARS-CoV-2 variants poses ongoing challenges to vaccine efficacy. We evaluated neutralizing antibody responses against JN.1 and its derivatives (KP.3, KP.3.1.1, LB.1, and XEC) in healthcare workers who received seven doses of BNT162b2, including XBB.1.5 monovalent vaccine. In COVID-19-naive individuals, KP.3.1.1 and LB.1 showed…

https://etidioh.wordpress.com/2024/11/06/neutralizing-antibody-evasion-of-sars-cov-2-jn1-derivatives-kp3-kp311-lb1-and-xec/

#Russia sees sharp rise in #SARS-CoV-2 #variants that bypass #immunity, https://ria.ru/20240913/rospotrebnadzor-1972432927.html

"In the last two to three weeks, the proportion of circulating variants of the new coronavirus strains #KP3 and #LB1, which are part of the #FLiRT sublineage, has increased by 2.5 times in the Russian Federation," the release says.

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

#Escape of #SARS-CoV-2 #variants #KP11, #LB1 and #KP33 from approved #mAbs http://biorxiv.org/cgi/content/short/2024.08.20.608835v1?rss=1

#Sipavibart neutralized JN.1.1 but lost antiviral efficacy against KP1.1, LB.1 and KP3.3. Our results highlight the need for a close clinical monitoring of Pemivibart and raise concerns about the clinical efficacy of Sipavibart.

Why does it feel like everyone is getting Covid? Covid summer surge explained

[email protected]
@monde

Lu aujourd'hui dans Vox :
🦠 les derniers variants du (de la) COVID-19 en plein essor aux États-Unis sont FLiRT (ensemble de dérivés du variant JN.1) et LB.1 ;
💉 les vaccins actuellement sur le marché, développés contre les variants omicron, sont peu efficaces contre FLiRT / JN.1, mais le prochain lot le sera.

https://www.vox.com/coronavirus-covid19/367150/covid-surge-summer-wave-pandemic-vaccine-booster-mask

#Covid19 #FLiRT #LB1

#Pemivibart is less active against recent #SARS-CoV-2 #JN1 #sublineages http://biorxiv.org/cgi/content/short/2024.08.12.607496v1?rss=1

Pemivibart neutralized both JN.1 and #KP2 in vitro with comparable activity, whereas its potency was decreased slightly against #LB1, #KP23, and #KP3 but substantially against #KP311. Critically, the 50% inhibitory concentration of pemivibart against KP.3.1.1 was ~6 g/mL, or ~32.7 fold higher than that of JN.1.

The virological characteristics
of SARS-CoV-2 KP.3.1.1

@systemsvirology

These results suggest that KP.3.1.1 has the potential to be predominant due to its higher infectivity and increased immune evasion. In particular, #S31del in spike, the common mutation in KP.3.1.1, LB.1 and KP.2.3, is likely to be a key mutation.

KP.3.1.1 (JN.1.11.1.3.1.1). This variant harbors these mutations.
KP.3.1.1 spike = KP.3 spike + S31del. 4/

#KP3111 #LB1 #KP23

https://threadreaderapp.com/thread/1813465697252688273.html

Good Afternoon SARS2PAians!

I apologize for my late post today and not posting at all last week. The situation did not change all that much last week so there was not that much new info to go on anyway.

Also, most virologists are slowly getting more absorbed into the more potentially devastating H5N1 pandemic currently playing out in the animal kingdom, which is totally understandable but...still takes away from SARS2/C19 discussion. 😣

🔴Just a quick reminder that if you need to keep windows and doors shut during this 🔥HEATWAVE🔥, you might want to start using or build a Corsi-Rosenthal Box as keeping houses and businesses tightly shut against the elements is diametrically opposed to virus control.

__________
VOCs

There are no recent drastic changes in the COVID19 landscape so far.

Nationally, KP.2.3 in the lead, and quite a few mutations based on KP.3 right after.: https://ibb.co/jgsnv72

The newest mutation to watch seems to be KP.4.1 which is in very low numbers, currently under 1%, for now.

There are no specifics on the Tableau site so for for PA as far as mutations are concerned.

In NY/NJ, LB.1.7 in the lead, and again KP.3.1.1 is shown to move fast over there at 10% of leaderboard share.: https://ibb.co/vCFVRmN

__________
+rate

Nationally, according to Walgreens, the +rate is going almost stright up. No doubt the East being shut inside for extreme hot/humid weather is NOT helping this, as is waning vaccination effectiveness due to mutational drift.: https://ibb.co/8M4ZFMb

🔴PLEASE get vaccinated when JN.1/KP.2 versions come out in the next few months.

Out of about 5,000 PCR tests done, over a third (39.6%) are positive.

This is a STRONG swing upward that started in April.

The swing upward is mirrored in PA, but only 52 tests have been done. If you aren't feeling well, PLASE use a home test and stay home if you are sick!: https://ibb.co/WnymxfP

__________
Wastewater

WastewaterSCAN has numbers considered HIGH nationally even though the CDC site is considering them LOW. (🙄): https://ibb.co/C7z96yy

Wastewater levels are LOW compared to the first Omicron wave but HIGH considering that we should not be experiencing this increased sickness in July at all.

In our HHS region, Region 3, we have quite a few stations reporting quickly rising numbers. Harrisburg and Chester rising steadily and now surpasses the highest stations in Maryland, which has been consistently high.: https://ibb.co/R7JXkND

Our region average has been going vertical in wastewater concentration in late June.: https://ibb.co/fSTXbPB

In Region 2 (NY/NJ), the Oakhurst Station has been going vertical and other stations steadily and slowly rising.: https://ibb.co/FzJL7BV

Again, extra caution by using quality air filteration (either by CR box or by a KN95, N95 or better respirator) will keep these numbers down for the summer.

Keep cool and have a GREAT WEEK! 🔥🔥🔥

#COVID19 #COVID #COVIDisNotOver #SARS2PA
#Pennsylvania #PA
#KP3 #LB1 #DeFLiRT #S31Del #KP41

#WearAMask #CleanTheAir #WashHands
#VaccinesSaveLives #StayHomeIfSick !

"A covid summer uptick is underway as FLiRT and LB.1 variants ascend..

"Covid infections are growing in nearly all states—with the sharpest increases in the West.

"The death toll of the ongoing summer uptick is not clear because fatality data takes several weeks to become accurate. In May, weekly deaths involving the coronavirus hovered in the low 300s, according to the CDC."
https://wapo.st/45N8pxn
#GiftArticle #covid #summer #flirt #lb1

Good Afternoon SARS2PAians!

I hope you're enjoying the beautiful weather today!! ☀️☀️☀️

__________
VOCs

Nationally, nothing really new as far as VOCs go, we still have KP.2.3 in the lead, with a very tight race for the top 5 slots on the leaderboard in random sequencing.: https://ibb.co/gjbxpV0

According to Sato Lab in Japan, KP.2.3 is blazingly fast (along with LB.1) and bears a mutation (S:S31del) that makes it immune resistant and more infectious.: https://x.com/SystemsVirology/status/1806464518270369889

Numbers rising already worldwide and in the US from these S-deletion mutations.

In PA, the LB.x.y set seems to be more successful than the KP.2.3 set. This doesn't mean we don't have both out there, but LB.1.7 is showing up more often in recent random sequencing.: https://ibb.co/s3VTsy4

KP.3.1 is also very fast, and the extremely tight race shows that this is a result of mutations that are ALL very fast and infectious.

In NY/NJ, LB.1.7 is at the top of the chart just like in PA. KP.2.3 is right behind it and other fast mutations are gaining, like LP.1.: https://ibb.co/HGDhcjm

Walgreens still has a huge portion of the lower 48 states in the highest positivity growth bracket.: https://ibb.co/1b64Kns

In PA, we're stable right now but numbers are comparable to a mid-winter illness level, and these are only the reported cases.: https://ibb.co/k8VV8Cv

__________
Wastewater

The PAWSS has a lot of increases across the board. Moderate increases in Allegheny, Indiana, Centre, Cumberland, MontCo and around Philly, and Delaware Cos. Some HIGH increases in Monroe Co.: https://ibb.co/JkWTcfh

🔴Vaccines with newer mutation formulas should be available in mid-July for Novavax and earliest Fall for mRNA (Moderna/Pfizer etc.). Moderna has announced they're interested in a JN.1 formula along with Novavax and is looking to start getting in arms in August. Pfizer is still leaning toward KP.2.

The FDA needs to be pushed to get these to kids BEFORE THE SCHOOL YEAR STARTS.

Please get you and your kid(s) vaccinated. Don't be That Guy.

Get whatever is available, as they'll definitely be more effective than year-old XBB shots.

If you have a strong reaction to the mRNA shots though you might want to switch to Novavax (I did!!) but it's usually harder to find.

That's all I have this week as not much has changed even though numbers are still going up. Consider wearing a quality respirator in crowds and in places with poor ventilation.

I hope you have a BEAUTIFUL day and a healthy early summer! ☀️☀️☀️

#COVID19 #COVID #COVIDisNotOver #SARS2PA
#Pennsylvania #PA
#KP3 #LB1 #DeFLiRT #S31Del

#WearAMask #CleanTheAir #WashHands
#VaccinesSaveLives #StayHomeIfSick !