#Neutralization of #SARS-CoV-2 #KP1, #KP11, #KP2 and #KP3 by #human and murine #sera

Source: npj Vaccines, AbstractWe report SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 neutralizing antibody titers. They displayed increased immune evasion compared to JN.1, especially KP.1 and KP.3, for participants who experienced BF.7/BA.5.2 breakthrough infection or received bivalent (delta/BA.5) vaccine boosting. Second XBB sub-variants breakthrough infection enhanced the neutralization…

https://etidioh.wordpress.com/2024/11/11/neutralization-of-sars-cov-2-kp1-kp11-kp2-and-kp3-by-human-and-murine-sera/

Neutralizing #antibody #evasion of #SARS-CoV-2 #JN1 derivatives #KP3, #KP311, #LB1, and #XEC

Source: BioRxIV, AbstractThe emergence of SARS-CoV-2 variants poses ongoing challenges to vaccine efficacy. We evaluated neutralizing antibody responses against JN.1 and its derivatives (KP.3, KP.3.1.1, LB.1, and XEC) in healthcare workers who received seven doses of BNT162b2, including XBB.1.5 monovalent vaccine. In COVID-19-naive individuals, KP.3.1.1 and LB.1 showed…

https://etidioh.wordpress.com/2024/11/06/neutralizing-antibody-evasion-of-sars-cov-2-jn1-derivatives-kp3-kp311-lb1-and-xec/

10/7/2024

Good Morning SARS2PAians! 🍁🍁🍁

I haven't been posting much because the picture didn't really change all that much for us so far. Numbers for PA wastewater are going down except for a bit in Philly.: https://ibb.co/sPRmszP

KP.3.x.y still very much at the top of the leaderboard.: https://ibb.co/09g7CCV

The newest variants to watch are MV.1 and especially recombinant XEC for the winter. XEC is really taking off in France and the UK is expecting doing some numbers with this. It's already hit 10% in some parts of Canada. It's at 2% so far in PA.: https://ibb.co/tDk0N5m

XEC was at 1% of random sequencing in the US at the beginning of September and at the end of the month was at 6%.

This doesn't seem like much but when you consider how blazingly FAST KP.3.1.1 is, this is thoroughbred level faster.

XEC is expected to grow steadily all fall and winter, and could end up being the troublesome winter variant.

That's all I have for now, until I see (but hopefully not) XEC potentially doing the numbers.

QUICK REMINDERS: Grab those tests kits available through the mail now and don't consume raw dairy!! 🍁🍁🍁

#COVID19 #COVID #COVIDisNotOver #SARS2PA
#Pennsylvania #PA #KP3 #XEC #MV1

#Wastewater

#WearAMask #CleanTheAir #WashHands #mRNA #Novavax
#VaccinesSaveLives #StayHomeIfSick !

9/16/2024

Good Morning SARS2PAians!

Hope you are enjoying this beautiful weather. ☀️😎☀️

__________
VOCs

Still, nothing much has changed, the top two variants which also make up the bulk of random sequencing are KP.3.1.1 and KP.2.3.:https://ibb.co/9NJNYpj

XEC is still around, though in PA it's still at the bottom of the sequencing list and doesn't seem to be going anywhere.

There is a new variant that is being watched closely, and that is MV.1. It's shown to be potentially as fast as KP.3.1.1 with some very strange, little-understood mutations. It's a good competitor to KP.3.1.1 and while not very different from current variants, the actual mutations are very concerning because some are so rare.: https://ibb.co/XSRQXVX

__________
Wastewater

Wastewater levels are HIGH according to WastewaterSCAN, and CDC also considers them HIGH (not "Very High".): https://ibb.co/bmqSXvn

On the PA wastewater dashboard we're overall stable with some increases, but on WastewaterSCAN Harrisburg again is rising quickly, which shows a need for source control.: https://ibb.co/9wCTx3s

___________

That's all I have right now as I run out the door today! Please get those updated flu/COVID vaccinations, stay safe and we'll keep an eye on MV.1 together! 👀 👀 👀

#COVID19 #COVID #COVIDisNotOver #SARS2PA
#Pennsylvania #PA #KP3 #XEC #MV1

#Wastewater

#WearAMask #CleanTheAir #WashHands #mRNA #Novavax
#VaccinesSaveLives #StayHomeIfSick !

Diese Praxis in Bremen Nord impft wieder gegen Corona, und zwar auch Nichtpatienten, mit dem JN.1-angepassten Impfstoff von Biontech. Es wird bei der Terminbuchung auf die Stikoks verwiesen. Im Zweifel nachfragen oder einfach versuchen durchzuziehen, je nach Mindset.

https://www.hausarztpraxis-lesumpark.de/impfung-gegen-covid-19/

#CovidIsNotOver #Impfung #Comirnaty #Bremen #Arztpraxis #jn1 #kp3 #Booster

#Russia sees sharp rise in #SARS-CoV-2 #variants that bypass #immunity, https://ria.ru/20240913/rospotrebnadzor-1972432927.html

"In the last two to three weeks, the proportion of circulating variants of the new coronavirus strains #KP3 and #LB1, which are part of the #FLiRT sublineage, has increased by 2.5 times in the Russian Federation," the release says.

Good Afternoon SARS2PAians!

1/2 for Sept. 9th, 2024

I hope you are having a healthy and productive late summer!☀️

__________
VOCs

The national mutation leaderboard hasn't changed much.: https://ibb.co/LP1L4LZ

There are no new mutations that are on the far horizon that can compete with KP.3.1.1 so far.

The closest competitor is the recombinant XEC, a combo of KS.1.1 and KP.3.1, and is maybe almost equally as fast as what we have now.

We have XEC already in PA.: https://ibb.co/JpnYfcJ

The good news is XEC, as I mentioned last time, has only 2 spike mutations different from KP.3.1.1, so any immunity granted against KP.x.y will also work very well against XEC.

Actually, the current versions are pretty stagnant. Stagnation is good as it gives us a breather, but it's also what happened between XBB and JN.1/KP.x.y.: https://ibb.co/BCqrTFN

Thanks to variant hunters, who constantly monitor virus genetics and then estimate growth rates (and some of which are not even paid to do this for us), we will have a few weeks to a month or two of any incoming fast, binding, or immune-evasive mutations.

Keep watching that space. It's important, especially as winter approaches.

__________
Wastewater

WastewaterSCAN still has our region at HIGH levels of SARS2.: https://ibb.co/wRCwRkK

Chester's numbers are not low, but much more manageable than in other areas. Harrisburg is doing much better as numbers keep going down there! Good work Hburg!: https://ibb.co/Pm9kF4H

Our region's numbers are going down after a peak already. This is a relief. We are still the HHS region with the lowest numbers.: https://ibb.co/3zcRKJL

PA, after quite a sizeable spike, is VERy quickly returning to numbers way below national average and more on par with the rest of the region.: https://ibb.co/VtVxDYX

We're doing something right. 💪

But remember, numbers are still in the moderate to HIGH range, so please keep working on source control.

According to CDC, there is NO state right now having anything less than "moderate" wastewater levels. Clearly this is defintely NOT a best-case scenario going into Fall.

Existing immune deficiency due to previous reinfections (and first time infections!) and already very high virus spread might make for quite a high-maintenance Fall and Winter this year.

__________
Kits, vaxes, etc.

Reminder that you can get 4 Federally funded tests kits by mail at the end of this month. Don't miss it!!

Covidtests.gov: https://aspr.hhs.gov/covid-19/test/Pages/default.aspx

There's also a tool from Vaccines.gov to find an mRNA KP.2 vaccination near you!!!

🔴Also reminder: if you have an uncomfortably strong reaction to mRNA vaccines, please do give Novavax a try. It's protein-based, and formulated much like a traditional tetanus shot, rather than mRNA.

https://us.novavaxcovidvaccine.com/find-a-vaccine

I am not in any way paid to promote Novavax. And I'm not the company President, but...I am in fact a client 😎

If you are unable to get Novavax, PLEASE.....get something.

🔴And gooooooo get a FLU SHOT too if you are able!

__________
Other Pathogens

 H5N1

There was a first case already of H5N1 infection in a person in Missouri, NOT linked, so far, to animal contact and not farm related.

https://www.cnn.com/2024/09/06/health/first-human-case-of-bird-flu-not-linked-to-animals/index.html

This is the current picture for H5N1. Found in 14 states.: https://ibb.co/pfrFxtT

This is ...pretty bad. This is getting progressively...kinda bad.

🔴Please DO NOT consume raw dairy products: raw eggs, undercooked/rare meat, unpasteurized dairy. Dippy eggs. Raw egg-based cookie dough. Just don't.

🔴Use extra caution with animals like rodents in your home, especially if you have to deal with them after they're trapped.

🔴Keep your cats indoors and dogs away from prey. H5N1 has a super-high kill rate especially in cats.

Stock up NOW on a few N95s (you will NOT want less than a genuine N95 for this thing), gloves, and MERV-13 filters for those CR boxes.

CDC can repeat "risk assessment low" all they want, we should NOT be screwing around with something than has an estimated baseline 20% kill rate, which is the reason I spend so much time on this subject in a SARS2 forum.

The current genetics of H5N1 is not scary, but giving this thing more chances to hit the lottery is the worst thing we could be doing now.

🔴Again: H5N1 cannot combine with the pathogen that causes COVID19, because one is a SARS and the other is an influenza. They are way too different from each other. But it CAN combine with influenza A and B....and we are entering that season soon.

We can do the best things in preparation NOW for a worst case scenario which means building up some basic PPE at home, avoiding exposure. Prepare =/= panic.

Please stay safe this coming Fall and keep that source control down!

☀️🍁☀️

#COVID19 #COVID #COVIDisNotOver #SARS2PA
#Pennsylvania #PA #KP3 #XEC #FLuQUE

#Wastewater #Norovirus #Noro

#H5N1 #HPAI #BirdFlu

#WearAMask #CleanTheAir #WashHands #mRNA #Novavax
#VaccinesSaveLives #StayHomeIfSick !

SARS-CoV-2 KP.3 has greatly increased binding affinity to ACE2. This means better transmission and also less virus to do its thing in the body.

"which exhibits a huge ~10-fold KD drop in SPR experiments."

https://www.biorxiv.org/content/10.1101/2024.09.03.610799v1

#SARSCoV2 #binding #KP3

#Neutralization and #Stability of #JN1-derived #LB1, #KP23, #KP3 and #KP311 #Subvariants http://biorxiv.org/cgi/content/short/2024.09.04.611219v1?rss=1

We report on the neutralizing #antibody (nAb) #escape, infectivity, #fusion, and stability of these subvariants-LB.1, KP.2.3, KP.3, and KP.3.1.1. Our findings demonstrate that all of these subvariants are highly evasive of nAbs elicited by bivalent #mRNA #vaccine, the #XBB15 monovalent mumps virus-based vaccine, or from infections during the BA.2.86/JN.1 wave.

Structural and molecular #basis of the #epistasis effect in enhanced affinity between #SARS-CoV-2 #KP3 and #ACE2 http://biorxiv.org/cgi/content/short/2024.09.03.610799v1?rss=1

KP.3, featuring F456L and Q493E, exhibits a markedly enhanced ACE2 binding affinity compared to #KP2 and #JN1 #variant due to synergistic effects between these mutations.