I’ve been replaying #Jak2 and after meeting Vin again, his delivery reminds me so much of @LoadingReadyRun’s “Max Clearance” skit.

“Hey, do you hate using Dark Eco? I do too, don’t touch the stuff.”

https://youtube.com/watch?v=XThTT_f8JEM

#JakAndDaxter #LoadingReadyRun #OpenGOAL

Max Clearance || Crapshots Ep752

YouTube
help. im starved for jak n' dax content #JakandDaxter #Jak2 #Fanart

My #husband is having a #BoneMarrow #biopsy this morning - his doctor wants to confirm that the #Jak2 #mutation is really actually gone. Fingers crossed!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912229/

Jak-2 mutation frequency in patients with thrombocytosis

We aimed to investigate the etiologic causes and the existence of Janus kinase 2 mutation (JAK2) in cases with thrombocytosis.In this retrospective study, patients who were admitted to hematology clinic with thrombocytosis between 2013 and 2015 were investigated ...

PubMed Central (PMC)

By way of #introduction, I am a voracious consumer of news & politics, a bleeding heart liberal who believes everyone should eat well and contribute to making other people's lives better. Many of my interests:

#news
#politics
#feedthehungry
#liberal
#geeks
#science
#epidemiology
#climate
#virology
#vaccinate
#RCCC
#kidneycancer
#cancer
#bloodcancer
#EssentialThrombocythemia
#MyeloproliferativeNeoplasm
#MPN
#JAK2+
#Poker
#genealogy
#astrology
#toastmasters
#proudgrandma

New study in #NatureCommunications on #JAK2-related #cardiovascular disease. Using a mouse model and human imaging data, the authors find that acquired JAK2 V617F mutation in the blood increases risk for aortic dilation and dissection: https://www.nature.com/articles/s41467-022-34469-1 #medicine #science #hematology #cardiology #ClonalHematopoiesis
JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm - Nature Communications

JAK2V617F mutation is associated with an increased risk for athero-thrombotic cardiovascular disease, but its role in aortic disease development remains unknown. Here, the authors show that JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.

Nature