Mastodawn

SLE (#lupus) is associated with genetic variants in the X-linked gene TASL. Julia Johnstone, Alex Clarke &co show that TASL is required for B cell activation, age-associated B cell formation and lupus-like disease #InMice, suggesting its potential as a therapeutic target
https://plos.io/47yDuXv

The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice

Systemic lupus erythematosus is a chronic autoimmune disease that mostly affects women and it is associated with genetic variants in the X-linked gene encoding the adaptor protein TASL. This study shows that TASL is required for B cell activation, age-associated B cell formation and lupus-like development in a mouse model, suggesting its potential as a therapeutic target.

PLOS Biology Mar 5

Why does #fat expand differently in distinct body regions? Yan Li, Carlos Ibáñez, Meng Xie &co identify Gpc3 as a gene that selectively promotes the expansion of white adipose tissue in specific body areas in mice fed a high fat diet.
#metabolism #InMice
https://plos.io/4cY5ffK

Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity

Why does fat expand differently in distinct body regions? This study identifies GPC3 as regional depot-specific obesity responsive gene that selectively promotes the expansion of inguinal, but not epididymal, white adipose tissue in mice fed a high fat diet.

PLOS Biology Mar 3

Ischemic #stroke induces substantial neuronal remodeling. Huanhuan Chen, Ye Wei, Mikhail Spivakov, Oleg O Glebov &co find a loss of synapses in the ischemic core, but functional enhancement of synapses in the contralateral cortex in a mouse model of stroke.
#Neuroscience #InMice
https://plos.io/4seJxse

Ischemic stroke triggers brain-wide synaptic remodeling within four hours

Ischemic stroke induces substantial neuronal remodeling, which is often studied in the context of mid-to-long term functional rehabilitation. This study characterizes early synaptic remodeling in a mouse model of stroke, revealing a loss of synapses in the ischemic core, but functional enhancement of synapses in the contralateral cortex.

quangobaud Dec 18

Mice playing Doom

(sadly, no gameplay images 🙁)

#GabrielTorch #BearBaitOfficial #Science #RunningDoomOn #InMice

https://youtu.be/KR64RBHaDdY

Rats Trained To Play Doom In VR Can Now Shoot Opponents

YouTube

quangobaud Dec 10

earliest evidence of chavs caught doing arson! 😱

Nature

https:// www.nature .com › articles › s41586-025-09855-6

Earliest evidence of making fire - Nature

Today

Here we present evidence of fire-making on a 400,000-year-old buried landsurface at Barnham (UK), where heated sediments and fire-cracked flint

(also this should say #InMice .. whoops ... I meam #OldestEvidenceButNotOldestInTheWorldJustOldestInTheUK )

https://www.nature.com/articles/s41586-025-09855-6

Earliest evidence of making fire - Nature

Baked sediment, heat-shattered artefacts and introduced pyrite in a 400,000-year-old Palaeolithic occupation site in Suffolk, UK provide evidence of intentional fire-making, marking a pivotal moment in human development.

Nature

Damian Yerrick Dec 3

Don't give your pet mouse 🐁️ a tattoo. A study by Capucetti et al. in PNAS found the ink lingers in lymph nodes for months and kills immune cells. Effect on vaccines varied; Comirnaty (for COVID) injected into a tattoo was weaker while the flu jab was stronger.
https://www.consumeraffairs.com/news/tattoo-ink-races-into-lymph-nodes-kills-immune-cells-and-alters-vaccine-responses-study-finds-120225.html

#MouseStudy #tattoo #vaccine #PNAS #lymph #immune #InMice

Tattoo ink races into lymph nodes, kills immune cells and alters vaccine responses, study finds

Mouse research shows tattoo pigments move into lymph nodes within minutes and persist for months Ink triggered immune-cell death, chronic inflammation an

ConsumerAffairs

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Avi Rappoport (avirr)Oct 25

@adapalmer #InMice

WearyBonnie Sep 19, 2025

You know that thing where people add #InMice to posts about scientific discoveries where the research has so far only been done on mice?
We need #InTheEast for stories about 'Australian' weather conditions 😐

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