Giuseppe Michieli#Taiwan, First locally acquired case of #H7N7 avian #influenza A virus has been released from isolation today (MoH, April 3 '26), https://etidiohnew.blogspot.com/2026/04/taiwan-first-locally-acquired-case-of.html
Different #genetic #determinants for high #virulence, #transmission and #replication of high pathogenicity #H7N7 avian #influenza virus in #turkeys and #chickens, https://etidiohnew.blogspot.com/2025/03/different-genetic-determinants-for-high.html
#Hemagglutinin and #neuraminidase of a non-pathogenic #H7N7 avian #influenza virus coevolved during acquisition of intranasal #pathogenicity in #chickens, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06118-z
This study demonstrates that viruses that are highly pathogenic when administered intranasally require additional adaptations for increased pathogenicity to be highly lethal to intranasally infected chickens.
Hemagglutinin and neuraminidase of a non-pathogenic H7N7 avian influenza virus coevolved during the acquisition of intranasal pathogenicity in chickens - Archives of Virology
Polybasic amino acid residues at the hemagglutinin (HA) cleavage site are insufficient to induce the highly pathogenic phenotype of avian influenza viruses in chickens. In our previous study, an H7N7 avian influenza virus named “Vac2sub-P0”, which is nonpathogenic despite carrying polybasic amino acids at the HA cleavage site, was passaged in chick air sacs, and a virus with high intravenous pathogenicity, Vac2sub-P3, was obtained. Intranasal infection with Vac2sub-P3 resulted in limited lethality in chickens; therefore, in this study, this virus was further passaged in chicken lungs, and the resultant virus, Vac2sub-P3L4, acquired high intranasal pathogenicity. Experimental infection of chickens with recombinant viruses demonstrated that mutations in HA and neuraminidase (NA) found in consecutive passages were responsible for the increased pathogenicity. The HA and NA functions of Vac2sub-P3L4 were compared with those of the parental virus in vitro; the virus growth at 40 °C was faster, the binding affinity to a sialic acid receptor was lower, and the rate of release by NA from the cell surface was lower, suggesting that these changes enabled the virus to replicate efficiently in chickens with high intranasal pathogenicity. This study demonstrates that viruses that are highly pathogenic when administered intranasally require additional adaptations for increased pathogenicity to be highly lethal to intranasally infected chickens.
Large-Scale #Serological #Survey of #Influenza A Virus in South #Korean Wild #Boar (Sus scrofa) https://pubmed.ncbi.nlm.nih.gov/38842623/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1fgJURi2yzLesFml6et0Bb6krzs_FrNIYgPYVFN50JPwVNFg9s&fc=None&ff=20240606155644&v=2.18.0.post9+e462414
Detected subtypes included 23 cases of pandemic 2009 #H1N1, six of human seasonal #H3N2, three of classical swine H1N1, 13 of triple-reassortant swine #H1N2, seven of triple-reassortant swine H3N2, and seven of swine-origin H3N2 variant. Notably, none of the serum samples tested positive for avian IAV subtypes #H3N8, #H5N3, #H7N7, and #H9N2 or canine IAV subtype H3N2.
Large-Scale Serological Survey of Influenza A Virus in South Korean Wild Boar (Sus scrofa) - PubMed
In this comprehensive large-scale study, conducted from 2015 to 2019, 7,209 wild boars across South Korea were sampled to assess their exposure to influenza A viruses (IAVs). Of these, 250 (3.5%) were found to be IAV-positive by ELISA, and 150 (2.1%) by the hemagglutination inhibition test. Detected …
Xavier Abad MdGÉs una via ben descrita per #gripaviaria #H7, i va ser el símptoma més comú en el brot de #H7N7 als Països Baixos el 2003. Aquí la referència... https://pubmed.ncbi.nlm.nih.gov/29477464/ per si volen llegir més i la captura pel que fa a #H7N7 a Països Baixos, el 2003, entre altres.
The eyes have it: influenza virus infection beyond the respiratory tract - PubMed
Avian and human influenza A viruses alike have shown a capacity to use the eye as a portal of entry and cause ocular disease in human beings. However, whereas influenza viruses generally represent a respiratory pathogen and only occasionally cause ocular complications, the H7 virus subtype stands al …
#H7N6 highly pathogenic avian #influenza in #Mozambique, 2023, https://doi.org/10.1080/22221751.2024.2321993
-- The #zoonotic #potential of this new virus should be considered. #H7N2, #H7N3, #H7N7 viruses have all been previously associated with #conjunctivitis and/or #respiratory symptoms in #humans while in 2003 in the Netherlands a fatal case occurred following an infection with H7N7.