New #GeneGroups in FB2026_01:
HOST DEFENSE PEPTIDES https://flybase.org/reports/FBgg0002156, NUCLEAR EXOSOME TARGETING COMPLEX https://flybase.org/reports/FBgg0002165 and MITOCHONDRIAL INTERMEMBRANE SPACE TIM CHAPERONE COMPLEXES https://flybase.org/reports/FBgg0002014.
Gene Group: HOST DEFENSE PEPTIDES

FlyBase: a database for drosophila genetics and molecular biology

No FlyBase release is complete without some new Gene Groups. This release features mitochondrial complexes MITOCHONDRIAL INNER MEMBRANE PEPTIDASE COMPLEX, https://flybase.org/reports/FBgg0002141, MITOCHONDRIAL DEGRADOSOME https://flybase.org/reports/FBgg0002143 and MITOCHONDRIAL PROCESSING PEPTIDASE https://flybase.org/reports/FBgg0002140
And some new family gene groups: SPECTRINS https://flybase.org/reports/FBgg0002154 and SINGLE VON WILLEBRAND FACTOR TYPE C DOMAIN PROTEINS https://flybase.org/reports/FBgg0002153
#GeneGroups
Complex: MITOCHONDRIAL INNER MEMBRANE PEPTIDASE COMPLEX

FlyBase: a database for drosophila genetics and molecular biology

and a GO-Causal Activity Model (GO-CAM https://geneontology.org/docs/gocam-overview/) that is based directly on GO annotation data.

Useful links to external resources (FlyCyc, Reactome, KEGG) and publications are provided, as well as options to export the gene list to analysis, download and orthology tools.

For more information, see this Commentary: http://flybase.org/commentaries/2024_12/MetabolicPathways.html

#FlyBaseTootorial #GeneGroups #MetabolicPathways

GO-CAM overview

Introduction to GO-CAMs

Gene Ontology Resource

New #GeneGroups subset: Metabolic Pathways!

These manually curated reports aim to facilitate metabolic research in Drosophila by providing high-quality gene lists and visual representations of fly metabolic pathways, integrated with the other rich data in FlyBase. For example, see CHITIN BIOSYNTHESIS http://flybase.org/reports/FBgg0002045.htm

You can access Metabolic Pathways by searching via the Pathways QuickSearch tab, or by browsing the Metabolic Pathways list http://flybase.org/lists/FBgg/metabolicpathways

We've added >30 new reports to the Gene Group collection, many of which are enzyme complexes and functional groups related to metabolic processes and mitochondrial function. These include the GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE COMPLEX https://flybase.org/reports/FBgg0002000.htm, SERINE C-PALMITOYLTRANSFERASE COMPLEX https://flybase.org/reports/FBgg0002007.htm, UDP-N-ACETYLGLUCOSAMINE TRANSFERASE COMPLEX https://flybase.org/reports/FBgg0002009.htm, GAMMA-BUTYROBETAINE HYDROXYLASES https://flybase.org/reports/FBgg0002012.htm,

#FB2024_05 #GeneGroups #MacromolecularComplexes

We've added some new #MacromolecularComplexes. New groups include MITOCHONDRIAL IRON-SULFUR ASSEMBLY COMPLEX http://flybase.org/reports/FBgg0001989.htm, MITOCHONDRIAL DNA REPLISOME http://flybase.org/reports/FBgg0001975.htm, MTV COMPLEXhttp://flybase.org/reports/FBgg0001970.htm, and IRM ADHESION COMPLEXES http://flybase.org/reports/FBgg0001980.htm. #GeneGroups
The number of member genes for each group is now visible on the browsable report lists for #GeneGroups, #MacromolecularComplexes and #PathwayReports. You can access the browsable lists from #QuickSearch tabs for each.
As part of a collaboration with the EMBL-EBI Complex Portal https://www.ebi.ac.uk/complexportal/home many fly complexes have been added to this resource and 194 Macromolecular Complex Reports have corresponding entries.
#FlyBaseTootorial #MacromolecularComplexes #GeneGroups
Complex Portal

EMBL-EBI

New in #GeneGroups! Have you wanted a one-stop resource to find Drosophila genes involved in transmembrane transport? We've compiled the Transmembrane Transporter Collection.

TRANSMEMBRANE TRANSPORTERS http://flybase.org/reports/FBgg0001934 was assembled from multiple sources, including data from Gene Ontology (GO) annotation, the Transporter Classification Database https://tcdb.org/ and publications. (we've reviewed and updated GO annotation to be more accurate and to provide better coverage). @go

We added several new complexes to #GeneGroups: New complexes have been added to the Gene Groups resource including MITOCHONDRIAL ALPHA-KETOACID DEHYDROGENASE COMPLEXES http://flybase.org/reports/FBgg0001924, the AUGMIN COMPLEX http://flybase.org/reports/FBgg0001940, the LKB1-STRAD-MO25 SERINE/THREONINE PROTEIN KINASE COMPLEX http://flybase.org/reports/FBgg0001919, and the TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE COMPLEX http://flybase.org/reports/FBgg0001900.