Therapeutic challenges & Emerging Strategies against #Carbapenem -Resistant #Acinetobacter baumannii.
Emerging agents like sulbactam‑durlobactam, eravacycline & cefiderocol offer new options against multifaceted CRAB resistance.
https://davidojcius.blogspot.com/2026/03/therapeutic-challenges-and-emerging.html
The glutathione pathway is required for biofilm formation in #Acinetobacter baumannii
https://www.sciencedirect.com/science/article/pii/S2666517426000179 #OpenAccess #biofilms #microbiology
Küresel sağlık tehdidi: Acinetobacter baumannii bakterisine antibiyotikler bile fayda etmiyor!: Bilim insanları, Malezya'da yapılan araştırmalar sonucunda antibiyotiklere karşı yüksek direnç gösteren "Acinetobacter baumannii" bakterisini tespit etti.
Bu bakteri, küresel sağlık için büyük bir tehdit oluştururken, özellikle hastanelerde enfeksiyon riskini… https://www.eshahaber.com.tr/haber/kuresel-saglik-tehdidi-acinetobacter-baumannii-bakterisine-antibiyotikler-bile-fayda-etmiyor-216622.html?utm_source=dlvr.it&utm_medium=mastodon EshaHaber.com.tr #Acinetobacter #AntibiyotikDirenci #KüreselSağlık #SağlıkTehdidi #HastaneEnfeksiyonları
Bilim insanları yaptığı yeni araştırmada Malezya’da antibiyotiklere bile direnen ölümcül Acinetobacter baumannii bakterisini keşfetti. Bu bakteri özellikle hastanelerde hızla yayılarak tüm dünya için küresel bir sağlık riski oluşturuyor.
Bacterial species exhibit large variations in their transformation rates. This study of Legionella pneumophila and Acinetobacter baumannii shows that their transformation rates evolve by sudden quick changes, likely caused by intragenomic conflicts between mobile genetic elements and the host bacterium.
Keime, die den Einsatz von Antibiotika überleben, breiten sich aus. Neue Wirkstoffe müssen her, mahnt die WHO. In ihrer Liste der besonders besorgniserregenden Bakterien findet sich nun auch der Tuberkulose-Haupterreger.
A joint academic-industry collaboration recently discovered a novel #antibiotic class--tethered macrocyclic peptides (MCPs)--that works against highly-resistant #Acinetobacter strains. The researchers also published the 3D #protein structure of one of these antibiotics in complex with its target, providing the basis for the rational engineering of these compounds to target other human pathogens. A job for #AI, possibly?
A tethered macrocyclic peptide antibiotic class described here—which shows potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii—blocks the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane through inhibition of the LptB2FGC complex.
Antimicrobial resistance (AMR): a novel antibiotic Zosurabalpin (RG6006) shows promise in pre-clinical trials
Antibiotic resistance particularly by Gram-negative bacteria has nearly created a crisis like situation. The novel antibiotic Zosurabalpin (RG6006)...........
#Acinetobacter #AMR #Antibiotic #AntibioticResistance #Antimicrobialresistan
we didn't end up covering this paper because we couldn't access it at the time ☝️
but we did talk about a related paper by Lu et al. published in ISME in 2022. Where they reported an increase in transformation of #acinetobacter baylyi when exposed to #antidepressants
Folks can hear us chat about it here: https://youtu.be/G5S9PM-1whE?t=690
Cross-protection and cross-feeding between #Klebsiella pneumoniae and #Acinetobacter baumannii promotes their co-existence | Nature Communications
Here, the authors characterise Acinetobacter baumanii and Klebsiella pneumoniae isolated from a single human lung infection and proceed to define their interactions to shed light on how this impacts their evolution, growth parameters, metabolism and antimicrobial responses.
David Ojcius
EshaHaber
PLOS Biology
Infektionsforschung (HZI)
Erik Ronzone
Scientific European
Microbiology Journal Club
Giuseppe Michieli
Vivek Mutalik