WordmarkApr 21
#nopanic #donotpanic a #bacterium has become #smart at #evolution #randomize #dna game: it flags certain areas of it's #dna as "please envolve rapidly" #who #Acinetobacter #baumannii #biology
David OjciusMar 15

Therapeutic challenges & Emerging Strategies against #Carbapenem -Resistant #Acinetobacter baumannii.

Emerging agents like sulbactam‑durlobactam, eravacycline & cefiderocol offer new options against multifaceted CRAB resistance.

https://davidojcius.blogspot.com/2026/03/therapeutic-challenges-and-emerging.html

#OpenAccess #microbiology #antibioticresistance

David OjciusJan 30

The glutathione pathway is required for biofilm formation in #Acinetobacter baumannii

https://www.sciencedirect.com/science/article/pii/S2666517426000179 #OpenAccess #biofilms #microbiology

EshaHaberApr 9, 2025

Küresel sağlık tehdidi: Acinetobacter baumannii bakterisine antibiyotikler bile fayda etmiyor!: Bilim insanları, Malezya'da yapılan araştırmalar sonucunda antibiyotiklere karşı yüksek direnç gösteren "Acinetobacter baumannii" bakterisini tespit etti.

Bu bakteri, küresel sağlık için büyük bir tehdit oluştururken, özellikle hastanelerde enfeksiyon riskini… https://www.eshahaber.com.tr/haber/kuresel-saglik-tehdidi-acinetobacter-baumannii-bakterisine-antibiyotikler-bile-fayda-etmiyor-216622.html?utm_source=dlvr.it&utm_medium=mastodon EshaHaber.com.tr #Acinetobacter #AntibiyotikDirenci #KüreselSağlık #SağlıkTehdidi #HastaneEnfeksiyonları

Küresel sağlık tehdidi: Acinetobacter baumannii bakterisine antibiyotikler bile fayda etmiyor!

Bilim insanları yaptığı yeni araştırmada Malezya’da antibiyotiklere bile direnen ölümcül Acinetobacter baumannii bakterisini keşfetti. Bu bakteri özellikle hastanelerde hızla yayılarak tüm dünya için küresel bir sağlık riski oluşturuyor.

www.eshahaber.com.tr - EshaHaber Güncel Gündem Sondakika Haberleri
PLOS BiologyOct 15, 2024
Why do #bacterial species' #TransformationRates vary so dramatically? @epcrocha @labXC &co show that #Legionella & #Acinetobacter transformation rates evolve by sudden changes, likely caused by conflicts between #MGEs and the host bacterium #PLOSBiology https://plos.io/4dMviTR
Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species

Bacterial species exhibit large variations in their transformation rates. This study of Legionella pneumophila and Acinetobacter baumannii shows that their transformation rates evolve by sudden quick changes, likely caused by intragenomic conflicts between mobile genetic elements and the host bacterium.

Infektionsforschung (HZI)May 21, 2024
Die WHO hat die Liste der Erreger aktualisiert, für die dringend neue #Antibiotika benötigt werden. Den größten Bedarf sieht die Organisation weiter bei #Acinetobacter baumannii, zudem ist der #Tuberkulose-Erreger neu auf der Liste. via Der Spiegel #AMR
https://www.spiegel.de/wissenschaft/mensch/antibiotika-resistenzen-krankenhauskeime-besonders-gefaehrlich-a-b2233a5a-9d6d-4f08-8b5a-b6582a38e8e8
Warnung vor Antibiotika-Resistenzen: WHO hat Liste der gefährlichsten Bakterien aktualisiert

Keime, die den Einsatz von Antibiotika überleben, breiten sich aus. Neue Wirkstoffe müssen her, mahnt die WHO. In ihrer Liste der besonders besorgniserregenden Bakterien findet sich nun auch der Tuberkulose-Haupterreger.

DER SPIEGEL
Erik RonzoneJan 9, 2024

A joint academic-industry collaboration recently discovered a novel #antibiotic class--tethered macrocyclic peptides (MCPs)--that works against highly-resistant #Acinetobacter strains. The researchers also published the 3D #protein structure of one of these antibiotics in complex with its target, providing the basis for the rational engineering of these compounds to target other human pathogens. A job for #AI, possibly?

Sources:
https://www.nature.com/articles/s41586-023-06873-0

https://www.nature.com/articles/s41586-023-06799-7

A novel antibiotic class targeting the lipopolysaccharide transporter - Nature

A tethered macrocyclic peptide antibiotic class described here—which shows potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii—blocks the transport of bacterial lipopolysaccharide from the inner membrane to its destination on the outer membrane through inhibition of the LptB2FGC complex.

Nature
Scientific EuropeanJan 8, 2024

Antimicrobial resistance (AMR): a novel antibiotic Zosurabalpin (RG6006) shows promise in pre-clinical trials 
Antibiotic resistance particularly by Gram-negative bacteria has nearly created a crisis like situation. The novel antibiotic Zosurabalpin (RG6006)...........
#Acinetobacter #AMR #Antibiotic #AntibioticResistance #Antimicrobialresistan

https://www.scientificeuropean.co.uk/medicine/antimicrobial-resistance-amr-a-novel-antibiotic-zosurabalpin-rg6006-shows-promise-in-pre-clinical-trials/

Antimicrobial resistance (AMR): a novel antibiotic Zosurabalpin (RG6006) shows promise in pre-clinical trials 

Antibiotic resistance particularly by Gram-negative bacteria has nearly created a crisis like situation. The novel antibiotic Zosurabalpin (RG6006) shows promis

Scientific European
Show threadMicrobiology Journal ClubJul 17, 2023

we didn't end up covering this paper because we couldn't access it at the time ☝️

but we did talk about a related paper by Lu et al. published in ISME in 2022. Where they reported an increase in transformation of #acinetobacter baylyi when exposed to #antidepressants

Folks can hear us chat about it here: https://youtu.be/G5S9PM-1whE?t=690

@PNASNews

#amr

Better Bacterial Boba, Fungi adapt to Ant behavior, & Prozac stresses out bacteria

YouTube
Giuseppe MichieliMar 6, 2023
Early initiation of three-drug #combinations for the #treatment of #carbapenem-resistant #Acinetobacter baumannii among #COVID19 patients https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad042/7069111?rss=1
Early initiation of three-drug combinations for the treatment of carbapenem-resistant A. baumannii among COVID-19 patients

AbstractObjectives. We evaluated the clinical characteristics and outcomes of patients with COVID-19 who received three-drug combination regimens for treatment

OUP Academic