It was a great pleasure to contribute to this work by Jemma Fendley, @mrcmlr and Boris Shraiman on pan-genomes, linkage, and recombination in phage genomes.
We analyzed data collected by the fantastic SEA-PHAGES program in https://phagesdb.org.
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Thrilled to announce that our preprint (together with fantastic @richardneher and Liam Shaw) has been officially published in Molecular Biology and Evolution! 🎉
If you're curious about how rapidly the genome of E. coli evolves (picking up new genes, rearranging, breaking synteny...) give it a look! 🧬
https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msae272/7942412
A summary thread 🧵 https://mstdn.science/@mrcmlr/112772499102225806
A great article by Jon Cohen covering @pathoplexus & our values, with quotes from Exec Board member Anderson Brito & the community, @eddieholmes &
Gustavo Palacios!
And a great excuse to deep-dive into some of the people behind Pathoplexus! 👩🏻🔬👨🏾🔬👨🏿🔬👩🏼🔬
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From Science Magazine @sciencemagazine: “We believe that building trust through transparency is essential for encouraging broader participation in data sharing,” says Pathoplexus co-founder Anderson Fernandes de Brito
https://science.org/content/article/new-scientist-run-virus-database-vows-be-transparently-run-and-simple-use
#Pathoplexus #OpenScience
Happy to announce a new preprint from the lab, together with fantastic @richardneher and Liam Shaw! 📝
https://www.biorxiv.org/content/10.1101/2024.07.08.602537v1
We were motivated by the following puzzling observation: microbial genomes can be extremely similar in the core genome, while still differing by large portions of accessory genome.
Therefore we ask the question:
1) how does this diversity accumulate?
2) at what rate do genomes undergo large structural changes?
A thread 🧵 [1/13]
Richard Neher
Dr Emma Hodcroft 
Pathoplexus