| website | neherlab.org |
| https://twitter.com/richardneher | |
| github | https://github.com/rneher |
| orcid | https://orcid.org/my-orcid?orcid=0000-0003-2525-1407 |
“The society was not a “dining club” or “political party”, Nurse said, noting that he was sure it had included “murderers” and other criminals in the past.”
Sure seems like a declaration of moral bankruptcy…
1/ 🚀 Exciting news: we’ve just released the first Nextclade dataset for Enterovirus D68 (EV-D68), developed in collaboration with the European Non-Polio Enterovirus Network (ENPEN).
👉🏻 Check out the dataset on Nextclade! https://clades.nextstrain.org/?dataset-name=enpen/enterovirus/ev-d68
Our future is being shaped to a terrifying degree by people who have just … completely lost their marbles…
https://www.theguardian.com/us-news/2025/oct/10/peter-thiel-lectures-antichrist
In der EU wird gerade darüber debattiert die Möglichkeit zu schaffen, ALLE deine Nachrichten zu scannen – ohne Verdacht, ohne Ausnahme. Auch WhatsApp & Signal wären betroffen. Das ist Massenüberwachung von 450 Mio. Menschen. Wir sagen: NEIN! #ChatkontrolleStoppen
Verschlüsselung ist ein rechtlich verankertes Grundrecht und schützt uns alle: Banking, Gesundheitsdaten, private Gespräche. Die #Chatkontrolle würde diese Sicherheit brechen – und Kriminellen Tür und Tor öffnen. 🔐
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Sequence data from the new #Ebola outbreak in DRC suggests it is indeed a new spillover.
And just incredible to see the virus sequenced and publicly shared less than 24 hours after confirmation of the outbreak.
Background The Democratic Republic of the Congo (DRC) is currently facing concurrent outbreaks including mpox, cholera and malaria (1-4). The Ministry of Public Health, DRC has declared the 16th Ebola Virus Disease (EVD) outbreak on 04 September 2025 after PCR confirmation of Ebola virus (EBOV), formely Zaïre ebolavirus, in patient’s specimens from Bulape Heath Zone, in Kasai Province. The re-emergence of EBOV in remote areas with very limited access is not unprecedent since 15 Ebola outbreaks...
🗓 Pathoplexus turns ONE! 🎂🎉
In the past year we’ve grown from 4 pathogens to a truly global, community-driven platform for transparent, equitable & impactful pathogen sequence sharing.
📰 Read the full update: https://pathoplexus.org/news/2025-08-27-happy-birthday-world
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Analyzing these data as pangenome graphs was very helpful to disentangle contributions of homologous recombination and accessory genome evolution at different scales. I hope this will continue to help us to shed light on the dynamic world of bacteria and phages.
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This wide-spread homologous recombination seems to happen despite often substantial divergence >5% between genomes. But sometimes populations seem to fragment into groups with much less exchange – whether this is driven by geographic separation, ecological factors, or divergence is unclear.
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Within the syntenic core genome, linkage between SNPs decays rapidly with distance. LD approaches background levels after about 1000 bases. The background level itself is often set by population structure with little linkage within subgroups but genome wide coupling across subgroups.
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Using these cluster-wide pangenome graphs, we find a strongly conserved synteny of core phams. Accessory genome diversity is typically concentrated in well defined hotspots.
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Kai Kupferschmidt
Nadia NJ
Liberale Demokraten 🇪🇺
Pathoplexus