Marco Molari

Happy to announce a new preprint from the lab, together with fantastic @richardneher and Liam Shaw! 📝
https://www.biorxiv.org/content/10.1101/2024.07.08.602537v1
We were motivated by the following puzzling observation: microbial genomes can be extremely similar in the core genome, while still differing by large portions of accessory genome.
Therefore we ask the question:
1) how does this diversity accumulate?
2) at what rate do genomes undergo large structural changes?

A thread 🧵 [1/13]

Jul 12, 2024 at 8:09amWeb
Show threadMarco MolariJul 12, 2024
[2/13]
Horizontal Gene Transfer, i.e. the exchange of genetic material from one individual to the next, is at the origin of many of these changes. This process however also complicates phylogenetic inference, invalidating the hypothesis of exclusively vertical inheritance.
Show threadAntonio CamargoJul 13, 2024
@mrcmlr @richardneher this is beautiful! Congratulations!