Community-oriented microblog for gene regulation scientists. Our lab's life and science is discussed in a separate account @teiflab. Here I host more general news and discussions on the topics of #chromatin, #biophysics, #TFbinding, #CTCF, #cancer, #stemcells, #epigenetics, #cfDNA, #openscience.
My open-science philosophy pre-Mastodon is described here: https://generegulation.org/scientific-twitter/
| Web site | https://generegulation.org |
| https://twitter.com/generegulation | |
| https://www.linkedin.com/groups/3795224/ |
Loss of epigenetic information as a cause of mammalian aging https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7
▶️ Cellular responses to double-stranded DNA breaks erode the epigenetic landscape
▶️ This loss of epigenetic information accelerates the hallmarks of aging
▶️ These changes are reversible by epigenetic reprogramming
▶️ By manipulating the epigenome, aging can be driven forward and backward
News from INC COST:
Opening for a PhD student, postdoc and technician in the Epi-Guide-Edit consortium. https://nwo.nl/en/news/eight-projects-awarded-within-kic-call-key-technologies
https://vacatures.uva.nl/UvA/job/Postdoctoral-Researcher-in-Epigenomics/760962002/
https://vacatures.uva.nl/job-invite/10987/
https://vacatures.uva.nl/job-invite/10997/
Contact:
Prof Pernette J. Verschure ([email protected]); Prof Marianne Rots ([email protected])
Within the call 'Key Technologies (KIC)', eight research projects have been awarded grants. Consortia of scientists, companies and civil society organisations will soon start joint research in which fundamental and application-oriented research with the aid of innovative and pioneering technologies plays a central role. The eight projects cover various themes, such as: improving the taste and nutritional value of vegetable proteins, reprogramming the genome with CRISPR-Cas without genetic modifications, making large infrastructural steel constructions use longer and safer, and improving medication safety for patients with multiple chronic diseases. More than 16 million euros is available for the research.
Our first paper of 2023 describes a method we developed to monitor DNA repair synthesis at high resolution- SAR-seq. We have applied this to study programmed DNA repair sites in neurons, repair synthesis during mitosis, and end-resection during homologous recombination.
“Our first paper of 2023 describes a method we developed to monitor DNA repair synthesis at high resolution- SAR-seq. We have applied this to study programmed DNA repair sites in neurons, repair synthesis during mitosis, and end-resection during homologous recombination.”
Happy New Year! Happy New #postdoc job?
Please join us in London seeking to determine the role of nascent RNAs in chromatin regulation!
To apply, please visit: https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?nPostingId=1528&nPostingTargetId=4168&id=Q1KFK026203F3VBQBLO8M8M07&LG=UK&mask=ext
Deadline: Jan 31st
🐦🔗: https://twitter.com/RegGenomics/status/1610249649050337281
Check out this Perspective! @[email protected] @[email protected] @[email protected] @[email protected] @[email protected]
& colleagues present the six key riddles that must be solved to optimize the application of #precisiononcology to otherwise lethal malignancies. https://go.nature.com/3VIYYbo
@[email protected]
🐦🔗: https://twitter.com/NatureRevCancer/status/1610277299131240448
1/ My new book 'From Cell line to Command line' is finally here https://divingintogeneticsandgenomics.ck.page/products/cell-line-to-command-line Grab it to start transforming yourself to a computational biologist!
A thread on how this book came into being: 👇🧵
🐦🔗: https://twitter.com/tangming2005/status/1607751495914606594
Our lab has two postdoc positions available at the @[email protected] to work on transcription-coupled DNA repair or global genome DNA repair in chromatin funded by @[email protected]. We are part of @[email protected]. Check out our lab and join us👇!
https://www.luijsterburglab.org/positions
🐦🔗: https://twitter.com/luijsterburglab/status/1606953977337315328
Our new preprint! Nucleosome repositioning in chronic lymphocytic leukaemia (CLL) https://www.biorxiv.org/content/10.1101/2022.12.20.518743v1
▶️Nucleosome changes at cancer-sensitive regions allow patient stratification
▶️Nucleosome repeat length (NRL) decreases with #cancer aggressiveness
▶️Interplay with #methylation, #TFbinding and more!
