Teif LabApr 20, 2023
Excited to present our new preprint on nucleosome reorganisation in breast cancer! https://www.biorxiv.org/content/10.1101/2023.04.17.537031v1 It's a large project, mapping nucleosome repositioning in paired normal and tumour tissues and cell-free DNA from the same patients #TFbinding #cfDNA #H1X #5mC #LiquidBiopsy
Gene RegulationJan 8, 2023

1st weekly digest of #GeneRegulation papers:

🧬#TranscriptionFactor atlas of differentiation https://www.sciencedirect.com/science/article/pii/S0092867422014702

🧬 #TFbinding directed heterochromatin (#ZFP462) https://www.nature.com/articles/s41556-022-01051-2

🧬#3Dgenome organisation of nuclear speckles & splicing https://www.biorxiv.org/content/10.1101/2023.01.04.522632v1

🧬 Nuclear partitioning by charge blocks (#MED1, #PolII) https://www.sciencedirect.com/science/article/pii/S0092867422015264

🧬 Transient loss of #Polycomb induces an #epigenetic cancer fate https://www.biorxiv.org/content/10.1101/2023.01.04.522799v1

🧬 RGT: a toolbox for NGS analysis https://www.biorxiv.org/content/10.1101/2022.12.31.522372v1

Gene RegulationDec 21, 2022

Our new preprint! Nucleosome repositioning in chronic lymphocytic leukaemia (CLL) https://www.biorxiv.org/content/10.1101/2022.12.20.518743v1
▶️Nucleosome changes at cancer-sensitive regions allow patient stratification
▶️Nucleosome repeat length (NRL) decreases with #cancer aggressiveness
▶️Interplay with #methylation, #TFbinding and more!

#CLL, #nucleosome, #leukaemia, #chromatin

TF binding botNov 6, 2022
This #TFbinding bot now should be mirrored both on Twitter (https://twitter.com/TF_binding_bot) and Mastodon (@TFbinding_bot)