Loss of epigenetic information as a cause of mammalian aging https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7

▶️ Cellular responses to double-stranded DNA breaks erode the epigenetic landscape

▶️ This loss of epigenetic information accelerates the hallmarks of aging

▶️ These changes are reversible by epigenetic reprogramming

▶️ By manipulating the epigenome, aging can be driven forward and backward