Nice sunset today on the Upper West Side.
Viruses, viruses, viruses and vaccines.
V4=3x ancestral + 1x BA.5 bivalent
Professor at the Department of Microbiology
Icahn School of Medicine at Mount Sinai
Florian Krammer
@florian_krammer
- 2.2K Followers
- 258 Following
- 34 Posts
Kai KupferschmidtWir haben zum Ende des Jahres noch eine letzte #2022-Folge unseres #Podcasts @pandemia für euch aufgenommen: Einen #Rückblick auf das Jahr mit vielen alten Bekannten und wichtigen Stimmen. Es geht um #Corona und andere Viren, um Konflikte, #Klimawandel und Geld.
In ein paar Tagen gibt es einen längeren Thread von mir zu all dem. Aber jetzt erstmal schöne und erholsame Feiertage (und für das Singen am Ende möchte ich mich in aller Form entschuldigen 😅 )
Folge ist hier: https://viertausendhertz.de/pan52/
In ein paar Tagen gibt es einen längeren Thread von mir zu all dem. Aber jetzt erstmal schöne und erholsame Feiertage (und für das Singen am Ende möchte ich mich in aller Form entschuldigen 😅 )
Folge ist hier: https://viertausendhertz.de/pan52/
Menschen, Viren, Sensationen: Jahresrückblick 2022 | Pandemia
Das Pandemia-Team spricht mit ForscherInnen, ÄrztInnen und alten Bekannten darüber, was sie im Jahr 2022 bewegt, beschäftigt und begeistert hat. Welche wissenschaftlichen Durchbrüche gab es? Welche Krankheiten haben die Welt in Atem gehalten? Sie sprechen unter anderem mit Isabella Eckerle, Mike Ryan, Cornelia Betsch, Florian Krammer und Chikwe Ihekweazu. Klub Pandemia Pandemia Plus bei Apple Podcasts WERBUNG: CHARLES² – PHARMA INSIGHTS (Podcast) Wie wir Arzneimittel entwickeln und verfügbar machen Web | Apple | Spotify Bewerte Pandemia bei Apple Podcasts & Spotify Folge Pandemia bei Mastodon , Twitter & Instagram
God 
I’m profoundly offended by Megachurches. Build God a Megahomeless shelter and stop being fake Christians.
Edward Nirenberg@florian_krammer my secondary concern here is that this could functionally result in a reduction of the dose of mRNA-LNPs and limit antigen production in vivo in a manner similar to how memory cells outcompete naive ones for antigen in OAS, which would reduce one of the major advantages of mRNA over other approaches. Moderna did report this in 2019:
Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties
Abstract. Accelerated blood clearance (ABC) is a phenomenon in which certain pharmaceutical agents are rapidly cleared from the blood upon second and subsequent
Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site - Nature Communications
Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glycosylation site affects binding of tested monoclonal antibodies, protective activity in a mouse model is maintained.
Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site - Nature Communications
Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glycosylation site affects binding of tested monoclonal antibodies, protective activity in a mouse model is maintained.
HubertineAuclert
Here is a short commentary about the induction of anti-PEG antibodies by mRNA vaccines. A few studies (including one of ours) found that now. I do not think this is a safety problem but it should be monitored to make sure it does not impact on the half-life of PEGylated drugs in people who need them.
Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines - Nature Reviews Immunology
The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.
Professor Mark OsbornInteresting piece in the #Nature journal about the #birdsite and its importance in #science.
https://www.nature.com/articles/d41586-022-04506-6
As a very recent arrival on #Mastodon and in the #Fediverse, I'm seeing far more engagement here than on Twitter, despite having far fewer followers here.
Being here feels like the earlier days on Twitter, where posts are generously shared and where there is a genuine sense of building and supporting a community
I hope this continues and that the wider #Science and #Environment communities and also #universities jump on board.
For a now slightly dated view (in Nature) of the merits of Mastodon for scientists, see also this:
https://www.nature.com/articles/d41586-022-03668-7
I just used https://fedifinder.glitch.me to import people I follow on Twitter to follow them here. It worked well.