Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site - Nature Communications

Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glycosylation site affects binding of tested monoclonal antibodies, protective activity in a mouse model is maintained.